When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics—case report

J. Tuan; M. Nkeshimana; F. Masaisa; F. Manirakiza; D. Ruhangaza; J. Murayire; M. S. Mukanumviye; A. P. Kubwayo; O. Niyigena; T. Habanabakize; M. Byukusenge; B. Niyoyita; I. S. Moise; J. Niyotwambaza; L. Kailani

When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics—case report

J. Tuan, M. Nkeshimana, F. Masaisa, F. Manirakiza, D. Ruhangaza, J. Murayire, M. S. Mukanumviye, A. P. Kubwayo, O. Niyigena, T. Habanabakize, M. Byukusenge, B. Niyoyita, I. S. Moise, J. Niyotwambaza, L. Kailani

Research output: Contribution to journal › Article › peer-review

Abstract

CASE PRESENTATION: We describe a 38-year-old Rwandan male patient who presented to the hospital with a two-week history of left axillary lymphadenopathy, fever, weight loss, and one-year history of dysphagia. Lymph node fine needle aspirate was consistent with tuberculous lymphadenitis. Peripheral blood smear suggested a concomitant diagnosis of Acute Myeloid Leukemia (AML), which was confirmed by bone marrow biopsy. Although several cases of concurrent pulmonary tuberculosis and AML exist, fewer cases of concomitant tuberculous lymphadenitis and AML have been reported. CONCLUSION: This case highlights the need to keep a high suspicion for malignancy in a patient with lymphadenopathy, leukocytosis, and constitutional symptoms; at the same time, a coexisting opportunistic infection such as tuberculosis should not be overlooked in the tropical clinical setting.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Rwanda Medical Journal
Volume	76
Issue number	4
Publication status	Published - 2019
Externally published	Yes

Keywords

(MeSH): Tuberculous Lymphadenitis
Acute Myeloid Leukemia
Fine-Needle Biopsy
Immune Reconstitution Inflammatory Syndrome
Immunohistochemistry
Leukocytosis
Lymphadenopathy
Pulmonary Embolism
Splenomegaly

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Tuan, J., Nkeshimana, M., Masaisa, F., Manirakiza, F., Ruhangaza, D., Murayire, J., Mukanumviye, M. S., Kubwayo, A. P., Niyigena, O., Habanabakize, T., Byukusenge, M., Niyoyita, B., Moise, I. S., Niyotwambaza, J., & Kailani, L. (2019). When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics—case report. Rwanda Medical Journal, 76(4), 1-5.

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title = "When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics—case report",

abstract = "CASE PRESENTATION: We describe a 38-year-old Rwandan male patient who presented to the hospital with a two-week history of left axillary lymphadenopathy, fever, weight loss, and one-year history of dysphagia. Lymph node fine needle aspirate was consistent with tuberculous lymphadenitis. Peripheral blood smear suggested a concomitant diagnosis of Acute Myeloid Leukemia (AML), which was confirmed by bone marrow biopsy. Although several cases of concurrent pulmonary tuberculosis and AML exist, fewer cases of concomitant tuberculous lymphadenitis and AML have been reported. CONCLUSION: This case highlights the need to keep a high suspicion for malignancy in a patient with lymphadenopathy, leukocytosis, and constitutional symptoms; at the same time, a coexisting opportunistic infection such as tuberculosis should not be overlooked in the tropical clinical setting.",

keywords = "(MeSH): Tuberculous Lymphadenitis, Acute Myeloid Leukemia, Fine-Needle Biopsy, Immune Reconstitution Inflammatory Syndrome, Immunohistochemistry, Leukocytosis, Lymphadenopathy, Pulmonary Embolism, Splenomegaly",

author = "J. Tuan and M. Nkeshimana and F. Masaisa and F. Manirakiza and D. Ruhangaza and J. Murayire and Mukanumviye, {M. S.} and Kubwayo, {A. P.} and O. Niyigena and T. Habanabakize and M. Byukusenge and B. Niyoyita and Moise, {I. S.} and J. Niyotwambaza and L. Kailani",

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year = "2019",

language = "English",

volume = "76",

pages = "1--5",

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T1 - When infection and malignancy intersect in Rwanda

T2 - A diagnostic challenge in the tropics—case report

AU - Tuan, J.

AU - Nkeshimana, M.

AU - Masaisa, F.

AU - Manirakiza, F.

AU - Ruhangaza, D.

AU - Murayire, J.

AU - Mukanumviye, M. S.

AU - Kubwayo, A. P.

AU - Niyigena, O.

AU - Habanabakize, T.

AU - Byukusenge, M.

AU - Niyoyita, B.

AU - Moise, I. S.

AU - Niyotwambaza, J.

AU - Kailani, L.

N1 - Publisher Copyright: © The Author(s).

PY - 2019

Y1 - 2019

N2 - CASE PRESENTATION: We describe a 38-year-old Rwandan male patient who presented to the hospital with a two-week history of left axillary lymphadenopathy, fever, weight loss, and one-year history of dysphagia. Lymph node fine needle aspirate was consistent with tuberculous lymphadenitis. Peripheral blood smear suggested a concomitant diagnosis of Acute Myeloid Leukemia (AML), which was confirmed by bone marrow biopsy. Although several cases of concurrent pulmonary tuberculosis and AML exist, fewer cases of concomitant tuberculous lymphadenitis and AML have been reported. CONCLUSION: This case highlights the need to keep a high suspicion for malignancy in a patient with lymphadenopathy, leukocytosis, and constitutional symptoms; at the same time, a coexisting opportunistic infection such as tuberculosis should not be overlooked in the tropical clinical setting.

AB - CASE PRESENTATION: We describe a 38-year-old Rwandan male patient who presented to the hospital with a two-week history of left axillary lymphadenopathy, fever, weight loss, and one-year history of dysphagia. Lymph node fine needle aspirate was consistent with tuberculous lymphadenitis. Peripheral blood smear suggested a concomitant diagnosis of Acute Myeloid Leukemia (AML), which was confirmed by bone marrow biopsy. Although several cases of concurrent pulmonary tuberculosis and AML exist, fewer cases of concomitant tuberculous lymphadenitis and AML have been reported. CONCLUSION: This case highlights the need to keep a high suspicion for malignancy in a patient with lymphadenopathy, leukocytosis, and constitutional symptoms; at the same time, a coexisting opportunistic infection such as tuberculosis should not be overlooked in the tropical clinical setting.

KW - (MeSH): Tuberculous Lymphadenitis

KW - Acute Myeloid Leukemia

KW - Fine-Needle Biopsy

KW - Immune Reconstitution Inflammatory Syndrome

KW - Immunohistochemistry

KW - Leukocytosis

KW - Lymphadenopathy

KW - Pulmonary Embolism

KW - Splenomegaly

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M3 - Article

AN - SCOPUS:85086860221

SN - 2079-097X

VL - 76

SP - 1

EP - 5

JO - Rwanda Medical Journal

JF - Rwanda Medical Journal

IS - 4

ER -

When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics—case report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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