Vortex-assisted dispersive molecularly imprinted polymer-based solid phase extraction of acetaminophen from water samples prior to hplc-dad determination

Neliswa Mpayipheli, Anele Mpupa, Philiswa Nosizo Nomngongo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

In the present study, acetaminophen (ACT) molecularly imprinted polymer (ACT-MIP) were successfully synthesized via surface imprinting polymerization. The structural and morphological properties of ACT-MIP were characterized using various analytical techniques. ACT-MIP were used as an adsorbent in a vortex-assisted dispersive molecularly imprinted solid-phase microextraction (VA-d-µ-MISPE), coupled with a high-performance liquid chromatography–diode array detector (HPLC-DAD) method for the determination of ACT in water samples. Influential parameters such as the mass of adsorbent, vortex speed, extraction time, desorption volume, and desorption time were optimized using a multivariate approach. Under optimum conditions, the maximum binding capacities of ACT-MIP and NIP (non-imprinted polymers) were 191 mg/g and 71.5 mg/g, respectively. The linearity was attained across concentrations ranging from 0.630 to 500 µg/L, with a coefficient of determination of 0.9959. For ACT-MIP, the limit of detection (LOD) and limit of quantification (LOQ), enhancement factor, and precision of the method were 0.19 ng/L, 0.63 ng/L, 79, and <5%, respectively. The method was applied in the analysis of spiked water samples, and satisfactory percentage recoveries in the range of 95.3–99.8% were obtained.

Original languageEnglish
Article number194
JournalSeparations
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Acetaminophen
  • Adsorption isotherms
  • Molecularly imprinted polymer
  • Scatchard analysis
  • Selectivity
  • Solid-phase microextraction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

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