TY - JOUR
T1 - Understanding the perspectives of forkhead transcription factors in delayed wound healing
AU - Rajendran, Naresh Kumar
AU - Dhilip Kumar, Sathish Sundar
AU - Houreld, Nicolette Nadene
AU - Abrahamse, Heidi
N1 - Publisher Copyright:
© 2018, The International CCN Society.
PY - 2019/6/6
Y1 - 2019/6/6
N2 - Wound healing is a complex overlapping biological process that involves a sequence of events coordinated by various cells, proteins, growth factors, cytokines and signaling molecules. Recent evidence indicates that forkhead box O1 (FOXO1) transcription factors play an important role in organizing these events to stimulate wound healing. The ubiquitously expressed forkhead box, class O (FOXO) transcription factors act as cell signaling molecules in various transcriptional processes that are involved in diverse cellular activities, including cell death, cell differentiation, DNA repair, apoptosis, and oxidative stress in response to stimuli, and interact with numerous proteins. Due to the activation of FOXO targeted genes, FOXOs are involved in maintaining the balance between oxidative stress and antioxidants. In humans, different isoforms of FOXO namely FOXO1, FOXO3, FOXO4 and FOXO6 are present, however only FOXO1 and FOXO3 possess biological functions such as morphogenesis, maintenance and tissue regeneration. This might make FOXOs an important therapeutic target to enhance wound healing in diabetes, and to avoid over scarring. In spite of extensive literature, little is known regarding the role of FOXO and its relationship in wound healing. This review provides a summary of FOXO proteins and their biological role in wound healing and oxidative stress.
AB - Wound healing is a complex overlapping biological process that involves a sequence of events coordinated by various cells, proteins, growth factors, cytokines and signaling molecules. Recent evidence indicates that forkhead box O1 (FOXO1) transcription factors play an important role in organizing these events to stimulate wound healing. The ubiquitously expressed forkhead box, class O (FOXO) transcription factors act as cell signaling molecules in various transcriptional processes that are involved in diverse cellular activities, including cell death, cell differentiation, DNA repair, apoptosis, and oxidative stress in response to stimuli, and interact with numerous proteins. Due to the activation of FOXO targeted genes, FOXOs are involved in maintaining the balance between oxidative stress and antioxidants. In humans, different isoforms of FOXO namely FOXO1, FOXO3, FOXO4 and FOXO6 are present, however only FOXO1 and FOXO3 possess biological functions such as morphogenesis, maintenance and tissue regeneration. This might make FOXOs an important therapeutic target to enhance wound healing in diabetes, and to avoid over scarring. In spite of extensive literature, little is known regarding the role of FOXO and its relationship in wound healing. This review provides a summary of FOXO proteins and their biological role in wound healing and oxidative stress.
KW - Diabetes
KW - FOXO
KW - FOXO1
KW - FOXO3
KW - Oxidative stress
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85051851381&partnerID=8YFLogxK
U2 - 10.1007/s12079-018-0484-0
DO - 10.1007/s12079-018-0484-0
M3 - Review article
AN - SCOPUS:85051851381
SN - 1873-9601
VL - 13
SP - 151
EP - 162
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
IS - 2
ER -