Understanding the binding mechanism of antagonist (AZD3293) against BACE-1: Molecular insights into alzheimer’s drug discovery

Keyphrases

• AZD3293 100%
• β-site APP-cleaving Enzyme 1 (BACE1) 100%
• Root Mean Square Fluctuation 33%
• Root Mean Square Deviation 33%
• Production Run 16%
• Enzyme-ligand Complex 16%
• Lanabecestat 16%
• Alzheimer's Disease Treatment 16%
• Apoenzyme 16%
• Atomic Position 16%
• BACE1 Inhibitor 16%
• Molecular Dynamics Analysis 16%
• Rate-limiting Enzymes 16%
• Root Mean Square Radius 16%
• Flap Dynamics 16%
• Amyloid Precursor Protein 16%
• Flexible Loop 16%
• Binding Residues 16%
• Radius of Gyration 16%
• Enzyme Stability 16%
• Dynamic Approach 16%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Dynamics 50%
• Conformational Change 50%
• Clinical Trial 50%
• Small Molecule 25%
• Dihedral Angle 25%
• Active Site 25%
• Flexible Loop 25%
• Amyloid 25%
• Amyloid Precursor Protein 25%
• Drug Interaction 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Drug Discovery 100%
• Beta Secretase 100%
• Lanabecestat 100%
• Alzheimer's Disease 37%
• Clinical Trial 25%
• Combination Therapy 12%
• Drug Interaction 12%
• Apoenzyme 12%
• Amyloid 12%
• Amyloid Precursor Protein 12%