Two new fatty acid derivatives from the stem bark of alchornea laxiflora (euphorbiaceae)

Louis Pergaud Sandjo; Hervé M.Poumale Poumale; Xavier Noudou Siwe; Hippolyte Nga Ntede; Yoshihito Shiono; Bonaventure Tchaleu Ngadjui; Rui M.W. Krause; Derek Tantoh Ndinteh; Joseph Tanyi Mbafor

doi:10.1007/s11746-011-1770-7

Two new fatty acid derivatives from the stem bark of alchornea laxiflora (euphorbiaceae)

Louis Pergaud Sandjo
, Hervé M.Poumale Poumale
, Xavier Noudou Siwe
, Hippolyte Nga Ntede
, Yoshihito Shiono
, Bonaventure Tchaleu Ngadjui
, Rui M.W. Krause
, Derek Tantoh Ndinteh
, Joseph Tanyi Mbafor

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Euphorbiaceae is a family of plants used in traditional remedies in central Africa to treat selected diseases. Some of the phytochemical components in the stem bark of Alchornea laxiflora that have biochemical activity were identified. A number of novel compounds were isolated, including a new fatty acid ester, (1) a new ceramide, (2) some triterpenoids, (3-5), ellagic acid (6) and its derivatives (7, 8) were isolated. The structures of these compounds were determined on the basis of spectroscopic methods as well as HR-ESI-TOF-MS analysis, chemical transformation and by comparison of their physical and spectral data with those reported in the literature. The cytotoxicity of some isolated compounds was investigated against human promyelocytic leukaemia (HL60) cell line by using the MTT method. Compounds 1, 4 and 5 showed a cytotoxic activity with IC₅₀ at 58.7, 6.6 and 6.8 μM, respectively.

Original language	English
Pages (from-to)	1153-1159
Number of pages	7
Journal	JAOCS, Journal of the American Oil Chemists' Society
Volume	88
Issue number	8
DOIs	https://doi.org/10.1007/s11746-011-1770-7
Publication status	Published - Aug 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alchornea laxiflora
Cytotoxicity
Euphorbiaceae
Fatty derivatives
Isolation

ASJC Scopus subject areas

General Chemical Engineering
Organic Chemistry

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10.1007/s11746-011-1770-7

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title = "Two new fatty acid derivatives from the stem bark of alchornea laxiflora (euphorbiaceae)",

abstract = "Euphorbiaceae is a family of plants used in traditional remedies in central Africa to treat selected diseases. Some of the phytochemical components in the stem bark of Alchornea laxiflora that have biochemical activity were identified. A number of novel compounds were isolated, including a new fatty acid ester, (1) a new ceramide, (2) some triterpenoids, (3-5), ellagic acid (6) and its derivatives (7, 8) were isolated. The structures of these compounds were determined on the basis of spectroscopic methods as well as HR-ESI-TOF-MS analysis, chemical transformation and by comparison of their physical and spectral data with those reported in the literature. The cytotoxicity of some isolated compounds was investigated against human promyelocytic leukaemia (HL60) cell line by using the MTT method. Compounds 1, 4 and 5 showed a cytotoxic activity with IC50 at 58.7, 6.6 and 6.8 μM, respectively.",

keywords = "Alchornea laxiflora, Cytotoxicity, Euphorbiaceae, Fatty derivatives, Isolation",

author = "Sandjo, \{Louis Pergaud\} and Poumale, \{Herv{\'e} M.Poumale\} and Siwe, \{Xavier Noudou\} and Ntede, \{Hippolyte Nga\} and Yoshihito Shiono and Ngadjui, \{Bonaventure Tchaleu\} and Krause, \{Rui M.W.\} and Ndinteh, \{Derek Tantoh\} and Mbafor, \{Joseph Tanyi\}",

year = "2011",

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doi = "10.1007/s11746-011-1770-7",

language = "English",

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AU - Sandjo, Louis Pergaud

AU - Poumale, Hervé M.Poumale

AU - Siwe, Xavier Noudou

AU - Ntede, Hippolyte Nga

AU - Shiono, Yoshihito

AU - Ngadjui, Bonaventure Tchaleu

AU - Krause, Rui M.W.

AU - Ndinteh, Derek Tantoh

AU - Mbafor, Joseph Tanyi

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AB - Euphorbiaceae is a family of plants used in traditional remedies in central Africa to treat selected diseases. Some of the phytochemical components in the stem bark of Alchornea laxiflora that have biochemical activity were identified. A number of novel compounds were isolated, including a new fatty acid ester, (1) a new ceramide, (2) some triterpenoids, (3-5), ellagic acid (6) and its derivatives (7, 8) were isolated. The structures of these compounds were determined on the basis of spectroscopic methods as well as HR-ESI-TOF-MS analysis, chemical transformation and by comparison of their physical and spectral data with those reported in the literature. The cytotoxicity of some isolated compounds was investigated against human promyelocytic leukaemia (HL60) cell line by using the MTT method. Compounds 1, 4 and 5 showed a cytotoxic activity with IC50 at 58.7, 6.6 and 6.8 μM, respectively.

KW - Alchornea laxiflora

KW - Cytotoxicity

KW - Euphorbiaceae

KW - Fatty derivatives

KW - Isolation

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JO - JAOCS, Journal of the American Oil Chemists' Society

JF - JAOCS, Journal of the American Oil Chemists' Society

IS - 8

ER -

Two new fatty acid derivatives from the stem bark of alchornea laxiflora (euphorbiaceae)

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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