TY - JOUR
T1 - Two new fatty acid derivatives from the stem bark of alchornea laxiflora (euphorbiaceae)
AU - Sandjo, Louis Pergaud
AU - Poumale, Hervé M.Poumale
AU - Siwe, Xavier Noudou
AU - Ntede, Hippolyte Nga
AU - Shiono, Yoshihito
AU - Ngadjui, Bonaventure Tchaleu
AU - Krause, Rui M.W.
AU - Ndinteh, Derek Tantoh
AU - Mbafor, Joseph Tanyi
PY - 2011/8
Y1 - 2011/8
N2 - Euphorbiaceae is a family of plants used in traditional remedies in central Africa to treat selected diseases. Some of the phytochemical components in the stem bark of Alchornea laxiflora that have biochemical activity were identified. A number of novel compounds were isolated, including a new fatty acid ester, (1) a new ceramide, (2) some triterpenoids, (3-5), ellagic acid (6) and its derivatives (7, 8) were isolated. The structures of these compounds were determined on the basis of spectroscopic methods as well as HR-ESI-TOF-MS analysis, chemical transformation and by comparison of their physical and spectral data with those reported in the literature. The cytotoxicity of some isolated compounds was investigated against human promyelocytic leukaemia (HL60) cell line by using the MTT method. Compounds 1, 4 and 5 showed a cytotoxic activity with IC50 at 58.7, 6.6 and 6.8 μM, respectively.
AB - Euphorbiaceae is a family of plants used in traditional remedies in central Africa to treat selected diseases. Some of the phytochemical components in the stem bark of Alchornea laxiflora that have biochemical activity were identified. A number of novel compounds were isolated, including a new fatty acid ester, (1) a new ceramide, (2) some triterpenoids, (3-5), ellagic acid (6) and its derivatives (7, 8) were isolated. The structures of these compounds were determined on the basis of spectroscopic methods as well as HR-ESI-TOF-MS analysis, chemical transformation and by comparison of their physical and spectral data with those reported in the literature. The cytotoxicity of some isolated compounds was investigated against human promyelocytic leukaemia (HL60) cell line by using the MTT method. Compounds 1, 4 and 5 showed a cytotoxic activity with IC50 at 58.7, 6.6 and 6.8 μM, respectively.
KW - Alchornea laxiflora
KW - Cytotoxicity
KW - Euphorbiaceae
KW - Fatty derivatives
KW - Isolation
UR - http://www.scopus.com/inward/record.url?scp=80051549282&partnerID=8YFLogxK
U2 - 10.1007/s11746-011-1770-7
DO - 10.1007/s11746-011-1770-7
M3 - Article
AN - SCOPUS:80051549282
SN - 0003-021X
VL - 88
SP - 1153
EP - 1159
JO - JAOCS, Journal of the American Oil Chemists' Society
JF - JAOCS, Journal of the American Oil Chemists' Society
IS - 8
ER -
