Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF3S-Containing Isoxazolidines

Alejandra Riesco-Domínguez, Jeroen Van De Wiel, Trevor A. Hamlin, Bas Van Beek, Stephen D. Lindell, Daniel Blanco-Ania, F. Matthias Bickelhaupt, Floris P.J.T. Rutjes

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.

Original languageEnglish
Pages (from-to)1779-1789
Number of pages11
JournalJournal of Organic Chemistry
Volume83
Issue number4
DOIs
Publication statusPublished - 16 Feb 2018
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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