Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF3S-Containing Isoxazolidines

Alejandra Riesco-Domínguez; Jeroen Van De Wiel; Trevor A. Hamlin; Bas Van Beek; Stephen D. Lindell; Daniel Blanco-Ania; F. Matthias Bickelhaupt; Floris P.J.T. Rutjes

doi:10.1021/acs.joc.7b02639

Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF₃S-Containing Isoxazolidines

Alejandra Riesco-Domínguez
, Jeroen Van De Wiel
, Trevor A. Hamlin
, Bas Van Beek
, Stephen D. Lindell
, Daniel Blanco-Ania
, F. Matthias Bickelhaupt
, Floris P.J.T. Rutjes

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.

Original language	English
Pages (from-to)	1779-1789
Number of pages	11
Journal	Journal of Organic Chemistry
Volume	83
Issue number	4
DOIs	https://doi.org/10.1021/acs.joc.7b02639
Publication status	Published - 16 Feb 2018
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/acs.joc.7b02639

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title = "Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF3S-Containing Isoxazolidines",

abstract = "Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.",

author = "Alejandra Riesco-Dom{\'i}nguez and \{Van De Wiel\}, Jeroen and Hamlin, \{Trevor A.\} and \{Van Beek\}, Bas and Lindell, \{Stephen D.\} and Daniel Blanco-Ania and Bickelhaupt, \{F. Matthias\} and Rutjes, \{Floris P.J.T.\}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

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doi = "10.1021/acs.joc.7b02639",

language = "English",

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journal = "Journal of Organic Chemistry",

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T1 - Trifluoromethyl Vinyl Sulfide

T2 - A Building Block for the Synthesis of CF3S-Containing Isoxazolidines

AU - Riesco-Domínguez, Alejandra

AU - Van De Wiel, Jeroen

AU - Hamlin, Trevor A.

AU - Van Beek, Bas

AU - Lindell, Stephen D.

AU - Blanco-Ania, Daniel

AU - Bickelhaupt, F. Matthias

AU - Rutjes, Floris P.J.T.

PY - 2018/2/16

Y1 - 2018/2/16

N2 - Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.

AB - Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.

UR - https://www.scopus.com/pages/publications/85042191806

U2 - 10.1021/acs.joc.7b02639

DO - 10.1021/acs.joc.7b02639

M3 - Article

C2 - 29320179

AN - SCOPUS:85042191806

SN - 0022-3263

VL - 83

SP - 1779

EP - 1789

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 4

ER -

Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF₃S-Containing Isoxazolidines

Abstract

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