TY - JOUR
T1 - Transfer hydrogenation of ketone; an in situ approach toward an eco-friendly reduction
AU - Onisuru, Oluwatayo Racheal
AU - Fapojuwo, Dele Peter
AU - Oseghale, Charles O.
AU - Alimi, Oyekunle Azeez
AU - Meijboom, Reinout
N1 - Publisher Copyright:
© 2022 The Royal Society of Chemistry.
PY - 2022/7/7
Y1 - 2022/7/7
N2 - The use of water as a solvent in chemical reactions has recently been brought to public attention, especially in the exploration of eco-friendly procedures. It is readily available, abundantly accessible, non-toxic, non-flammable, and at a low cost. As opposed to the previous limitation of reactant solubilities associated with aqueous media, a hydrogel such as a hydroxypropyl methylcellulose (HPMC) solution can significantly improve the reactant solubility. This investigation employed water and HPMC as the reaction solvent, and the reaction medium viscosity was impressively enhanced. Silica-supported Pd particles (Pd@SiO2) were synthesized and effectively catalyzed the reduction of acetophenone in the presence of sodium borohydride (NaBH4) as the hydrogen source. The conversion of acetophenone to 1-phenyl ethanol remained at a very high value of >99.34% with 100% selectivity towards 1-phenyl ethanol.
AB - The use of water as a solvent in chemical reactions has recently been brought to public attention, especially in the exploration of eco-friendly procedures. It is readily available, abundantly accessible, non-toxic, non-flammable, and at a low cost. As opposed to the previous limitation of reactant solubilities associated with aqueous media, a hydrogel such as a hydroxypropyl methylcellulose (HPMC) solution can significantly improve the reactant solubility. This investigation employed water and HPMC as the reaction solvent, and the reaction medium viscosity was impressively enhanced. Silica-supported Pd particles (Pd@SiO2) were synthesized and effectively catalyzed the reduction of acetophenone in the presence of sodium borohydride (NaBH4) as the hydrogen source. The conversion of acetophenone to 1-phenyl ethanol remained at a very high value of >99.34% with 100% selectivity towards 1-phenyl ethanol.
UR - http://www.scopus.com/inward/record.url?scp=85135145630&partnerID=8YFLogxK
U2 - 10.1039/d2ra02701a
DO - 10.1039/d2ra02701a
M3 - Article
AN - SCOPUS:85135145630
SN - 2046-2069
VL - 12
SP - 19890
EP - 19900
JO - RSC Advances
JF - RSC Advances
IS - 31
ER -