TY - JOUR
T1 - Three New Polyphenol Derivatives from the Fruits of Macaranga Monandra and their Antioxidant Potential
AU - Guizoko Toko, Einstein
AU - Emar Djappa Tchapo, Carlain
AU - Tontsa Tsamo, Armelle
AU - Kemzeu, Raoul
AU - Wang, Yan
AU - Boyom Fekam, Fabrice
AU - Tantoh Ndinteh, Derek
AU - Iqbal Choudhary, Muhammad
AU - Nkengfack, Ephrem Augustin
AU - Mpho Mmutlane, Edwin
AU - Mkounga, Pierre
N1 - Publisher Copyright:
© 2024 Wiley-VHCA AG, Zurich, Switzerland.
PY - 2024/7
Y1 - 2024/7
N2 - Phytochemical investigation of the methanol extract from the fruits of Macaranga monandra (Euphorbiaceae Muell. et Arg.) afforded one new geranylated 1’,2’-dihydrophenanthrene and two new flavonoid derivatives, named macamondrin (1), macamondrione A (2) and B (3) respectively. The structures of these compounds were elucidated mainly by NMR, mass spectral data and in comparison with data from the literature. Along with compounds 1–3, nine known compounds among which oleanolic acid (4); daucosterol (5); 3β-acetoxy-11α,12α-epoxytaraxerol (6); 3,3’,4-tri-O-methylellagic acid (7); 3,3’,4,4’-tetra-O-methylellagic acid (8); 4’-O-methyl-6-isoprenylapigenin (9); 4’-O-methyl-8 isoprenylkaempférol (10); 4’-O-methyl-6-isoprénylkaempférol (11); 6-isoprénylkaempférol (12), were also isolated. Crude extracts as well as isolated compounds were evaluated for their antioxidant activity using the ABTS, DPPH and FRAP methods. It appears that the 50 % radical scavenging concentrations ranging from 6.26 to 11.7 μg/ml on the ABTS radical, from 1.77 to 48.22 μg/ml on the DPPH radical, and from 1.54 to 67.97 μg/ml with the FRAP method. For the compounds tested, very good antioxidant activities were observed, which clearly shows that these molecules can have an anti oxidative stress potentiel.
AB - Phytochemical investigation of the methanol extract from the fruits of Macaranga monandra (Euphorbiaceae Muell. et Arg.) afforded one new geranylated 1’,2’-dihydrophenanthrene and two new flavonoid derivatives, named macamondrin (1), macamondrione A (2) and B (3) respectively. The structures of these compounds were elucidated mainly by NMR, mass spectral data and in comparison with data from the literature. Along with compounds 1–3, nine known compounds among which oleanolic acid (4); daucosterol (5); 3β-acetoxy-11α,12α-epoxytaraxerol (6); 3,3’,4-tri-O-methylellagic acid (7); 3,3’,4,4’-tetra-O-methylellagic acid (8); 4’-O-methyl-6-isoprenylapigenin (9); 4’-O-methyl-8 isoprenylkaempférol (10); 4’-O-methyl-6-isoprénylkaempférol (11); 6-isoprénylkaempférol (12), were also isolated. Crude extracts as well as isolated compounds were evaluated for their antioxidant activity using the ABTS, DPPH and FRAP methods. It appears that the 50 % radical scavenging concentrations ranging from 6.26 to 11.7 μg/ml on the ABTS radical, from 1.77 to 48.22 μg/ml on the DPPH radical, and from 1.54 to 67.97 μg/ml with the FRAP method. For the compounds tested, very good antioxidant activities were observed, which clearly shows that these molecules can have an anti oxidative stress potentiel.
KW - Antioxidant activity
KW - Euphorbiaceae
KW - Flavonoids
KW - Macamondrin
KW - Macamondrione
KW - Macaranga monandra
UR - http://www.scopus.com/inward/record.url?scp=85195538009&partnerID=8YFLogxK
U2 - 10.1002/cbdv.202301816
DO - 10.1002/cbdv.202301816
M3 - Article
C2 - 38861276
AN - SCOPUS:85195538009
SN - 1612-1872
VL - 21
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 7
M1 - e202301816
ER -