Therapeutic trial of rifabutin after rifampicin-associated dress syndrome in tuberculosis-human immunodeficiency virus coinfected patients

Rannakoe J. Lehloenya; Sipho Dlamini; Rudzani Muloiwa; Betty Kakande; Mzudumile R. Ngwanya; Gail Todd; Keertan Dheda

doi:10.1093/ofid/ofw130

Therapeutic trial of rifabutin after rifampicin-associated dress syndrome in tuberculosis-human immunodeficiency virus coinfected patients

Rannakoe J. Lehloenya, Sipho Dlamini, Rudzani Muloiwa, Betty Kakande, Mzudumile R. Ngwanya, Gail Todd, Keertan Dheda

University of Cape Town

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	3
Issue number	3
DOIs	https://doi.org/10.1093/ofid/ofw130
Publication status	Published - 1 May 2016
Externally published	Yes

Keywords

Alternative
Rifabutin
Rifampicin-associated drug eruption
Tuberculosis HIV coinfection

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofw130

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abstract = "Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.",

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AU - Lehloenya, Rannakoe J.

AU - Dlamini, Sipho

AU - Muloiwa, Rudzani

AU - Kakande, Betty

AU - Ngwanya, Mzudumile R.

AU - Todd, Gail

AU - Dheda, Keertan

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AB - Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.

KW - Alternative

KW - Rifabutin

KW - Rifampicin-associated drug eruption

KW - Tuberculosis HIV coinfection

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Therapeutic trial of rifabutin after rifampicin-associated dress syndrome in tuberculosis-human immunodeficiency virus coinfected patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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