The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis

Atousa Janzadeh; Michael R. Hamblin; Narges Janzadeh; Hossein Arzani; MahsaTashakori-Miyanroudi; Mahmoud Yousefifard; Fatemeh Ramezani

doi:10.1007/398_2021_67

The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis

Atousa Janzadeh, Michael R. Hamblin, Narges Janzadeh, Hossein Arzani, MahsaTashakori-Miyanroudi, Mahmoud Yousefifard, Fatemeh Ramezani

Laser Research Centre

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Citations (Scopus)

Abstract

Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS. After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity. Treatment with silver nanoparticles significantly reduced cell viability (SMD = −1.79%; 95% CI: −2.17 to −1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD −0.258; 95% CI: −0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.

Original language	English
Title of host publication	Reviews of Environmental Contamination and Toxicology
Publisher	Springer
Pages	93-119
Number of pages	27
DOIs	https://doi.org/10.1007/398_2021_67
Publication status	Published - 2021

Publication series

Name	Reviews of Environmental Contamination and Toxicology
Volume	257
ISSN (Print)	0179-5953
ISSN (Electronic)	2197-6554

Keywords

Apoptosis
MTT assay
Nerve cell
Neuron
Silver nanoparticle
Toxic

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1007/398_2021_67

Cite this

Janzadeh, A., Hamblin, M. R., Janzadeh, N., Arzani, H., MahsaTashakori-Miyanroudi, Yousefifard, M., & Ramezani, F. (2021). The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis. In Reviews of Environmental Contamination and Toxicology (pp. 93-119). (Reviews of Environmental Contamination and Toxicology; Vol. 257). Springer. https://doi.org/10.1007/398_2021_67

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title = "The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis",

abstract = "Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS. After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity. Treatment with silver nanoparticles significantly reduced cell viability (SMD = −1.79%; 95% CI: −2.17 to −1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD −0.258; 95% CI: −0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.",

keywords = "Apoptosis, MTT assay, Nerve cell, Neuron, Silver nanoparticle, Toxic",

author = "Atousa Janzadeh and Hamblin, {Michael R.} and Narges Janzadeh and Hossein Arzani and MahsaTashakori-Miyanroudi and Mahmoud Yousefifard and Fatemeh Ramezani",

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doi = "10.1007/398_2021_67",

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Janzadeh, A, Hamblin, MR, Janzadeh, N, Arzani, H, MahsaTashakori-Miyanroudi, Yousefifard, M & Ramezani, F 2021, The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis. in Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol. 257, Springer, pp. 93-119. https://doi.org/10.1007/398_2021_67

The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis. / Janzadeh, Atousa; Hamblin, Michael R.; Janzadeh, Narges et al.
Reviews of Environmental Contamination and Toxicology. Springer, 2021. p. 93-119 (Reviews of Environmental Contamination and Toxicology; Vol. 257).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - The Toxic Effect of Silver Nanoparticles on Nerve Cells

T2 - A Systematic Review and Meta-Analysis

AU - Janzadeh, Atousa

AU - Hamblin, Michael R.

AU - Janzadeh, Narges

AU - Arzani, Hossein

AU - MahsaTashakori-Miyanroudi,

AU - Yousefifard, Mahmoud

AU - Ramezani, Fatemeh

PY - 2021

Y1 - 2021

N2 - Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS. After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity. Treatment with silver nanoparticles significantly reduced cell viability (SMD = −1.79%; 95% CI: −2.17 to −1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD −0.258; 95% CI: −0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.

AB - Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS. After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity. Treatment with silver nanoparticles significantly reduced cell viability (SMD = −1.79%; 95% CI: −2.17 to −1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD −0.258; 95% CI: −0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.

KW - Apoptosis

KW - MTT assay

KW - Nerve cell

KW - Neuron

KW - Silver nanoparticle

KW - Toxic

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DO - 10.1007/398_2021_67

M3 - Chapter

C2 - 34622369

AN - SCOPUS:85119695916

T3 - Reviews of Environmental Contamination and Toxicology

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EP - 119

BT - Reviews of Environmental Contamination and Toxicology

PB - Springer

ER -

The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis

Abstract

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Keywords

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