The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis

Atousa Janzadeh, Michael R. Hamblin, Narges Janzadeh, Hossein Arzani, MahsaTashakori-Miyanroudi, Mahmoud Yousefifard, Fatemeh Ramezani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Citations (Scopus)


Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS. After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity. Treatment with silver nanoparticles significantly reduced cell viability (SMD = −1.79%; 95% CI: −2.17 to −1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD −0.258; 95% CI: −0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.

Original languageEnglish
Title of host publicationReviews of Environmental Contamination and Toxicology
Number of pages27
Publication statusPublished - 2021

Publication series

NameReviews of Environmental Contamination and Toxicology
ISSN (Print)0179-5953
ISSN (Electronic)2197-6554


  • Apoptosis
  • MTT assay
  • Nerve cell
  • Neuron
  • Silver nanoparticle
  • Toxic

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis'. Together they form a unique fingerprint.

Cite this