The synthesis of a γ-keto-α-amino acid, a key intermediate in the synthesis of monatin, a new natural sweetener

Cedric W. Holzapfel; Johan Olivier

doi:10.1080/00397919308012584

The synthesis of a γ-keto-α-amino acid, a key intermediate in the synthesis of monatin, a new natural sweetener

Cedric W. Holzapfel
, Johan Olivier

Chemical Sciences

Council for Scientific and Industrial Research

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

An efficient method was developed for the synthesis of the keto-amino acid 2, a key intermediate in the synthesis of the novel sweet compound, monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.

Original language	English
Pages (from-to)	2511-2526
Number of pages	16
Journal	Synthetic Communications
Volume	23
Issue number	18
DOIs	https://doi.org/10.1080/00397919308012584
Publication status	Published - 1 Sept 1993

ASJC Scopus subject areas

Organic Chemistry

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title = "The synthesis of a γ-keto-α-amino acid, a key intermediate in the synthesis of monatin, a new natural sweetener",

abstract = "An efficient method was developed for the synthesis of the keto-amino acid 2, a key intermediate in the synthesis of the novel sweet compound, monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.",

author = "Holzapfel, \{Cedric W.\} and Johan Olivier",

year = "1993",

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AU - Olivier, Johan

PY - 1993/9/1

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N2 - An efficient method was developed for the synthesis of the keto-amino acid 2, a key intermediate in the synthesis of the novel sweet compound, monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.

AB - An efficient method was developed for the synthesis of the keto-amino acid 2, a key intermediate in the synthesis of the novel sweet compound, monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.

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DO - 10.1080/00397919308012584

M3 - Article

AN - SCOPUS:0027275856

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The synthesis of a γ-keto-α-amino acid, a key intermediate in the synthesis of monatin, a new natural sweetener

Abstract

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