The synthesis of a γ-keto-α-amino acid, a key intermediate in the synthesis of monatin, a new natural sweetener

Cedric W. Holzapfel, Johan Olivier

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

An efficient method was developed for the synthesis of the keto-amino acid 2, a key intermediate in the synthesis of the novel sweet compound, monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.

Original languageEnglish
Pages (from-to)2511-2526
Number of pages16
JournalSynthetic Communications
Volume23
Issue number18
DOIs
Publication statusPublished - 1 Sept 1993

ASJC Scopus subject areas

  • Organic Chemistry

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