The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

Cedric W. Holzapfel; Wynand J. van Zyl; Marita Roos

doi:10.1016/S0040-4020(01)85446-6

The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

Cedric W. Holzapfel, Wynand J. van Zyl, Marita Roos

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Dolastatin 3, a unique cyclic peptide, was synthesised in high yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force feild calculations, and is characterised by three intramolecular hydrogen bonds.

Original language	English
Pages (from-to)	649-660
Number of pages	12
Journal	Tetrahedron
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/S0040-4020(01)85446-6
Publication status	Published - 1990

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(01)85446-6

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@article{9f9ec344ddb440829be1627741d08884,

title = "The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)",

abstract = "Dolastatin 3, a unique cyclic peptide, was synthesised in high yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force feild calculations, and is characterised by three intramolecular hydrogen bonds.",

author = "Holzapfel, {Cedric W.} and {van Zyl}, {Wynand J.} and Marita Roos",

year = "1990",

doi = "10.1016/S0040-4020(01)85446-6",

language = "English",

volume = "46",

pages = "649--660",

journal = "Tetrahedron",

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T1 - The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

AU - Holzapfel, Cedric W.

AU - van Zyl, Wynand J.

AU - Roos, Marita

PY - 1990

Y1 - 1990

N2 - Dolastatin 3, a unique cyclic peptide, was synthesised in high yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force feild calculations, and is characterised by three intramolecular hydrogen bonds.

AB - Dolastatin 3, a unique cyclic peptide, was synthesised in high yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force feild calculations, and is characterised by three intramolecular hydrogen bonds.

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U2 - 10.1016/S0040-4020(01)85446-6

DO - 10.1016/S0040-4020(01)85446-6

M3 - Article

AN - SCOPUS:0025343650

SN - 0040-4020

VL - 46

SP - 649

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JO - Tetrahedron

JF - Tetrahedron

IS - 2

ER -

The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

Abstract

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