The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Proliferation of osteoblasts is essential for maturation and mineralization of bone matrix. Ossification, the natural phase of bone-forming and hardening is a carefully regulated phase where deregulation of this process may result in insufficient or excessive bone mineralization or ectopic calcification. Osteoblasts can also be differentiated into osteocytes, populating short interconnecting passages within the bone matrix. Over the past few decades, we have seen a significant improvement in awareness and techniques using photobiomodulation (PBM) to stimulate cell function. One of the applications of PBM is the promotion of osteoblast proliferation and maturation. PBM research results on osteoblasts showed increased mitochondrial ATP production, increased osteoblast activity and proliferation, increased and pro-osteoblast expression in the presence of red and NIR radiation. Osteocyte differentiation was also accomplished using blue and green light, showing that different light parameters have various signalling effects. The current review addresses osteoblast function and control, a new understanding of PBM on osteoblasts and its therapeutic impact using various parameters to optimize osteoblast function that may be clinically important. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1570-1589
Number of pages20
JournalStem Cell Reviews and Reports
Volume17
Issue number5
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Cell Signalling
  • Differentiation
  • Osteoblast function
  • Photobiomodulation
  • Proliferation activity

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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