TY - JOUR
T1 - The role of microRNA-338-3p in cancer
T2 - growth, invasion, chemoresistance, and mediators
AU - Mirzaei, Sepideh
AU - Zarrabi, Ali
AU - Asnaf, Sholeh Etehad
AU - Hashemi, Farid
AU - Zabolian, Amirhossein
AU - Hushmandi, Kiavash
AU - Raei, Mehdi
AU - Goharrizi, Mohammad Ali Sheikh Beig
AU - Makvandi, Pooyan
AU - Samarghandian, Saeed
AU - Najafi, Masoud
AU - Ashrafizadeh, Milad
AU - Aref, Amir Reza
AU - Hamblin, Michael R.
N1 - Publisher Copyright:
© 2020
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Cancer still remains as one of the leading causes of death worldwide. Metastasis and proliferation are abnormally increased in cancer cells that subsequently, mediate resistance of cancer cells to different therapies such as radio-, chemo- and immune-therapy. MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate expression of target genes at post-transcriptional level and capable of interaction with mRNA-coding genes. Vital biological mechanisms including apoptosis, migration and differentiation are modulated by these small molecules. MiRNAs are key players in regulating cancer proliferation and metastasis as well as cancer therapy response. MiRNAs can function as both tumor-suppressing and tumor-promoting factors. In the present review, regulatory impact of miRNA-338-3p on cancer growth and migration is discussed. This new emerging miRNA can regulate response of cancer cells to chemotherapy and radiotherapy. It seems that miRNA-338-3p has dual role in cancer chemotherapy, acting as tumor-promoting or tumor-suppressor factor. Experiments reveal anti-tumor activity of miRNA-338-3p in cancer. Hence, increasing miRNA-338-3p expression is of importance in effective cancer therapy. Long non-coding RNAs, circular RNAs and hypoxia are potential upstream mediators of miRNA-338-3p in cancer. Anti-tumor agents including baicalin and arbutin can promote expression of miRNA-338-3p in suppressing cancer progression. These topics are discussed to shed some light on function of miRNA-338-3p in cancer cells.
AB - Cancer still remains as one of the leading causes of death worldwide. Metastasis and proliferation are abnormally increased in cancer cells that subsequently, mediate resistance of cancer cells to different therapies such as radio-, chemo- and immune-therapy. MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate expression of target genes at post-transcriptional level and capable of interaction with mRNA-coding genes. Vital biological mechanisms including apoptosis, migration and differentiation are modulated by these small molecules. MiRNAs are key players in regulating cancer proliferation and metastasis as well as cancer therapy response. MiRNAs can function as both tumor-suppressing and tumor-promoting factors. In the present review, regulatory impact of miRNA-338-3p on cancer growth and migration is discussed. This new emerging miRNA can regulate response of cancer cells to chemotherapy and radiotherapy. It seems that miRNA-338-3p has dual role in cancer chemotherapy, acting as tumor-promoting or tumor-suppressor factor. Experiments reveal anti-tumor activity of miRNA-338-3p in cancer. Hence, increasing miRNA-338-3p expression is of importance in effective cancer therapy. Long non-coding RNAs, circular RNAs and hypoxia are potential upstream mediators of miRNA-338-3p in cancer. Anti-tumor agents including baicalin and arbutin can promote expression of miRNA-338-3p in suppressing cancer progression. These topics are discussed to shed some light on function of miRNA-338-3p in cancer cells.
KW - Cancer
KW - Chemotherapy
KW - Circular RNA
KW - Long non-coding RNA
KW - MicroRNA 338-3p
UR - http://www.scopus.com/inward/record.url?scp=85098970130&partnerID=8YFLogxK
U2 - 10.1016/j.lfs.2020.119005
DO - 10.1016/j.lfs.2020.119005
M3 - Review article
C2 - 33421526
AN - SCOPUS:85098970130
SN - 0024-3205
VL - 268
JO - Life Sciences
JF - Life Sciences
M1 - 119005
ER -
