Abstract
According to WHO, cancer is a deadly disease and the second cause of death globally. Conventional treatment methods, such as chemotherapy, surgery, radiography, etc., have been bedeviled with numerous adverse effects. Hence, efforts have been made to find a suitable technique with little or no side effects for cancer diagnoses and treatment. In searching for an alternative medicine, using magnetic nanoparticles (MNPs) in cancer diagnosis and treatment has recently gained a lot of interest among researchers. This is due to their excellent properties, such as biocompatibility, non-toxic nature, and stability, to mention a few. In this review, we extensively discussed the various methods of synthesis of MNPs, comparing their merits and demerits. The functionalization of the MNPs and the reason for it were detailedly described. Also covered in this review is the application of MNPs in cancer diagnosis, including MRI and MPI. Also explained is the application of MNPs in various cancer treatment strategies, magnetic hyperthermia, magnetic-guided drug delivery, and theranostic platforms. Furthermore, the use of modeling and simulation in predicting and optimizing the performance of MNPs to ensure their effectiveness in cancer treatment was discussed. Finally, we looked at the toxicity-related concerns and the future perspective on the applications of these MNPs.
Original language | English |
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Article number | 101053 |
Journal | Nano-Structures and Nano-Objects |
Volume | 36 |
DOIs | |
Publication status | Published - Oct 2023 |
Keywords
- Cancer
- Functionalization
- Hyperthermia
- MPI
- MRI
- Magnetic nanoparticles
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- General Materials Science
- Condensed Matter Physics
- Physical and Theoretical Chemistry