The Role of Cannabis Species on Oxidative Stress in Cancer Cells

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


Many therapeutic mechanisms kill cancer cells through reactive oxygen species (ROS) generation, ROS plays a vital role in cancer cell signaling and metabolism, which is an irony. Cancer therapies can therefore target oxidative stress through varying mechanisms. The cannabis plant consists of many bioactive compounds with multiple beneficial health properties which have been overlooked for decades. It had been limited to illegal recreational use and legal pharmaceutical exploitation for the manufacturing of medicine. Cannabis consists of derivatives known as cannabinoids which target the endocannabinoid system in the body. Alongside its psychoactive effects, most of the cannabinoid compounds have potent therapeutic effects, one of which observed is the induction of oxidative stress in cancer cells, eventually leading to the cell death. This review discusses a brief account of cannabis and its derivatives and how they cause apoptosis in cancer cells by inducing oxidative cellular damage.

Original languageEnglish
Title of host publicationHandbook of Oxidative Stress in Cancer
Subtitle of host publicationTherapeutic Aspects: Volume 1
PublisherSpringer Singapore
Number of pages14
ISBN (Electronic)9789811654220
ISBN (Print)9789811654213
Publication statusPublished - 1 Jan 2022


  • Cancer cell death
  • Cannabidiol (CBD)
  • Cannabinoids
  • Cannabis
  • Tetrahydrocannabidiol (THC) anticancer properties

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology


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