@inproceedings{7c6934315d5b47e79633ff17d339d34c,
title = "The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer",
abstract = "Photodynamic therapy (PDT) has been shown to be an effective locally ablative anti-cancer treatment that has the additional advantage of inducing tumor-directed immune response. We hypothesized that PDT could be combined with anti-transforming growth factor (TGF) beta antibody that does not significantly affect the population of cytotoxic T lymphocytes (CTL) but at the same time, has the potential to decrease the immunosuppressive effects of regulatory T-cells (Treg) mediated by TGF beta. This hypothesis was tested with aTGF-beta antibody combined with BPD-mediated PDT in a BALB/c renal cell carcinoma model. Evidence of positive benefits of the combination therapy over individual treatments alone was obtained.",
keywords = "Anti-tumor immunity, Kidney cancer, Photodynamic therapy, Regulatory T-cells, Transforming growth factor beta",
author = "Pawel Mroz and Hamblin, {Michael R.}",
year = "2011",
doi = "10.1117/12.876523",
language = "English",
isbn = "9780819484376",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Biophotonics and Immune Responses VI",
note = "Biophotonics and Immune Responses VI ; Conference date: 23-01-2011 Through 24-01-2011",
}
