TY - JOUR
T1 - The Photosensitizing Efficacy of Micelles Containing a Porphyrinic Photosensitizer and KI against Resistant Melanoma Cells
AU - Castro, Kelly A.D.F.
AU - Costa, Letícia D.
AU - Prandini, Juliana A.
AU - Biazzotto, Juliana C.
AU - Tomé, Augusto C.
AU - Hamblin, Michael R.
AU - da Graça P. M. S. Neves, Maria
AU - Faustino, M. Amparo F.
AU - da Silva, Roberto S.
N1 - Publisher Copyright:
© 2020 Wiley-VCH GmbH
PY - 2021/1/26
Y1 - 2021/1/26
N2 - Photodynamic therapy (PDT) is a promising alternative to overcome the resistance of melanoma to conventional therapies. Currently applied photosensitizers (PS) are often based on tetrapyrrolic macrocycles like porphyrins. Unfortunately, in some cases the use of this type of derivative is limited due to their poor solubility in the biological environment. Feasible approaches to surpass this drawback are based on lipid formulations. Besides that, and inspired in the efficacy of potassium iodide (KI) for antimicrobial photodynamic therapy (aPDT), the combined effect of singlet oxygen (1O2) with KI was assessed in this work, as an alternative strategy to potentiate the effect of PDT against resistant melanoma cells.
AB - Photodynamic therapy (PDT) is a promising alternative to overcome the resistance of melanoma to conventional therapies. Currently applied photosensitizers (PS) are often based on tetrapyrrolic macrocycles like porphyrins. Unfortunately, in some cases the use of this type of derivative is limited due to their poor solubility in the biological environment. Feasible approaches to surpass this drawback are based on lipid formulations. Besides that, and inspired in the efficacy of potassium iodide (KI) for antimicrobial photodynamic therapy (aPDT), the combined effect of singlet oxygen (1O2) with KI was assessed in this work, as an alternative strategy to potentiate the effect of PDT against resistant melanoma cells.
KW - PDT
KW - iodine
KW - melanoma
KW - porphyrin
KW - singlet oxygen
UR - http://www.scopus.com/inward/record.url?scp=85099230331&partnerID=8YFLogxK
U2 - 10.1002/chem.202004389
DO - 10.1002/chem.202004389
M3 - Article
C2 - 33185284
AN - SCOPUS:85099230331
SN - 0947-6539
VL - 27
SP - 1990
EP - 1994
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 6
ER -
