The immunosuppressive side of PDT

Pawel Mroz; Michael R. Hamblin

doi:10.1039/c0pp00345j

The immunosuppressive side of PDT

Pawel Mroz
, Michael R. Hamblin

Massachusetts General Hospital
Harvard University
Harvard-MIT Division of Health Sciences and Technology

Research output: Contribution to journal › Review article › peer-review

85 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.

Original language	English
Pages (from-to)	751-758
Number of pages	8
Journal	Photochemical and Photobiological Sciences
Volume	10
Issue number	5
DOIs	https://doi.org/10.1039/c0pp00345j
Publication status	Published - May 2011
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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title = "The immunosuppressive side of PDT",

abstract = "Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.",

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AB - Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.

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DO - 10.1039/c0pp00345j

M3 - Review article

AN - SCOPUS:79955556969

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SP - 751

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JO - Photochemical and Photobiological Sciences

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The immunosuppressive side of PDT

Abstract

ASJC Scopus subject areas

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