The HF/BF3-catalysed reaction of substituted benzenes with carbon monoxide

J. Alexander Willemse; Barend C.B. Bezuidenhoudt; Cedric W. Holzapfel

doi:10.1055/s-2006-942480

The HF/BF₃-catalysed reaction of substituted benzenes with carbon monoxide

J. Alexander Willemse, Barend C.B. Bezuidenhoudt, Cedric W. Holzapfel

Chemical Sciences

Sasol Limited

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The HF/BF₃-catalysed reactions of phenol and anisole as well as substituted benzenes with CO were investigated as possible routes to commercially important aldehydes. The results confirmed that HF and BF ₃ are required in (at least) stoichiometric amounts for effective formylation with CO. With the aim of effecting truly catalytic reaction conditions, the formylation reactions were carried out in ionic liquids. It was shown that phenol is a good substrate for formylation in certain ionic liquids.

Original language	English
Pages (from-to)	2543-2550
Number of pages	8
Journal	Synthesis
Issue number	15
DOIs	https://doi.org/10.1055/s-2006-942480
Publication status	Published - 1 Aug 2006

Keywords

Aldehydes
Electrophilic aromatic substitutions
Ionic liquids
Lewis acids
Phenols

ASJC Scopus subject areas

Catalysis
Organic Chemistry

Access to Document

10.1055/s-2006-942480

Cite this

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abstract = "The HF/BF3-catalysed reactions of phenol and anisole as well as substituted benzenes with CO were investigated as possible routes to commercially important aldehydes. The results confirmed that HF and BF 3 are required in (at least) stoichiometric amounts for effective formylation with CO. With the aim of effecting truly catalytic reaction conditions, the formylation reactions were carried out in ionic liquids. It was shown that phenol is a good substrate for formylation in certain ionic liquids.",

keywords = "Aldehydes, Electrophilic aromatic substitutions, Ionic liquids, Lewis acids, Phenols",

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AU - Holzapfel, Cedric W.

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AB - The HF/BF3-catalysed reactions of phenol and anisole as well as substituted benzenes with CO were investigated as possible routes to commercially important aldehydes. The results confirmed that HF and BF 3 are required in (at least) stoichiometric amounts for effective formylation with CO. With the aim of effecting truly catalytic reaction conditions, the formylation reactions were carried out in ionic liquids. It was shown that phenol is a good substrate for formylation in certain ionic liquids.

KW - Aldehydes

KW - Electrophilic aromatic substitutions

KW - Ionic liquids

KW - Lewis acids

KW - Phenols

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