The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids

Ian G.C. Coutts; Michael R. Hamblin; Edward J. Tinley; James M. Bobbitt

doi:10.1039/p19790002744

The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids

Ian G.C. Coutts, Michael R. Hamblin, Edward J. Tinley, James M. Bobbitt

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Tetrahydroisoquinoline-1 -carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.

Original language	English
Pages (from-to)	2744-2750
Number of pages	7
Journal	Journal of the Chemical Society, Perkin Transactions 1
DOIs	https://doi.org/10.1039/p19790002744
Publication status	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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title = "The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids",

abstract = "Tetrahydroisoquinoline-1 -carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.",

author = "Coutts, \{Ian G.C.\} and Hamblin, \{Michael R.\} and Tinley, \{Edward J.\} and Bobbitt, \{James M.\}",

year = "1979",

doi = "10.1039/p19790002744",

language = "English",

pages = "2744--2750",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

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publisher = "Chemical Society",

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T1 - The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids

AU - Coutts, Ian G.C.

AU - Hamblin, Michael R.

AU - Tinley, Edward J.

AU - Bobbitt, James M.

PY - 1979

Y1 - 1979

N2 - Tetrahydroisoquinoline-1 -carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.

AB - Tetrahydroisoquinoline-1 -carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.

UR - https://www.scopus.com/pages/publications/37049096454

U2 - 10.1039/p19790002744

DO - 10.1039/p19790002744

M3 - Article

AN - SCOPUS:37049096454

SN - 1472-7781

SP - 2744

EP - 2750

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

ER -

The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids

Abstract

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