The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids

Ian G.C. Coutts, Michael R. Hamblin, Edward J. Tinley, James M. Bobbitt

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Tetrahydroisoquinoline-1 -carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.

Original languageEnglish
Pages (from-to)2744-2750
Number of pages7
JournalJournal of the Chemical Society, Perkin Transactions 1
DOIs
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry

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