The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells

Itumeleng Seotsanyana-Mokhosi; Tina Kresfelder; Heidi Abrahamse; Tebello Nyokong

doi:10.1016/j.jphotobiol.2005.12.004

The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells

Itumeleng Seotsanyana-Mokhosi, Tina Kresfelder, Heidi Abrahamse, Tebello Nyokong

Laser Research Centre

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The photodynamic activity of water soluble mixed sulfonated metallophthalocyanines complexes: GePcS_mix, SnPcS_mix and SiPcS_mix on human oesophageal carcinoma (SNO) cells are reported, and compared with the activity of the unmetallated H₂PcS_mix and of the newly synthesized water soluble adjacently substituted binaphthalo phthalocyanine (complex 3). The alkaline phosphate (ALP) showed damage to the cell membrane in the presence of complex 3 without irradiation. The GePcS_mix complex caused a relatively large increase in inflammation and a high intracellular ATP.

Original language	English
Pages (from-to)	55-62
Number of pages	8
Journal	Journal of Photochemistry and Photobiology B: Biology
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.jphotobiol.2005.12.004
Publication status	Published - 3 Apr 2006

Keywords

Cell proliferation
Cell viability
Germanium
Phthalocyanine
Silicon
Tin

ASJC Scopus subject areas

Radiation
Radiological and Ultrasound Technology
Biophysics
Radiology, Nuclear Medicine and Imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jphotobiol.2005.12.004

Cite this

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title = "The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells",

abstract = "The photodynamic activity of water soluble mixed sulfonated metallophthalocyanines complexes: GePcSmix, SnPcSmix and SiPcSmix on human oesophageal carcinoma (SNO) cells are reported, and compared with the activity of the unmetallated H2PcSmix and of the newly synthesized water soluble adjacently substituted binaphthalo phthalocyanine (complex 3). The alkaline phosphate (ALP) showed damage to the cell membrane in the presence of complex 3 without irradiation. The GePcSmix complex caused a relatively large increase in inflammation and a high intracellular ATP.",

keywords = "Cell proliferation, Cell viability, Germanium, Phthalocyanine, Silicon, Tin",

author = "Itumeleng Seotsanyana-Mokhosi and Tina Kresfelder and Heidi Abrahamse and Tebello Nyokong",

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doi = "10.1016/j.jphotobiol.2005.12.004",

language = "English",

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}

The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells. / Seotsanyana-Mokhosi, Itumeleng; Kresfelder, Tina; Abrahamse, Heidi et al.
In: Journal of Photochemistry and Photobiology B: Biology, Vol. 83, No. 1, 03.04.2006, p. 55-62.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells

AU - Seotsanyana-Mokhosi, Itumeleng

AU - Kresfelder, Tina

AU - Abrahamse, Heidi

AU - Nyokong, Tebello

PY - 2006/4/3

Y1 - 2006/4/3

N2 - The photodynamic activity of water soluble mixed sulfonated metallophthalocyanines complexes: GePcSmix, SnPcSmix and SiPcSmix on human oesophageal carcinoma (SNO) cells are reported, and compared with the activity of the unmetallated H2PcSmix and of the newly synthesized water soluble adjacently substituted binaphthalo phthalocyanine (complex 3). The alkaline phosphate (ALP) showed damage to the cell membrane in the presence of complex 3 without irradiation. The GePcSmix complex caused a relatively large increase in inflammation and a high intracellular ATP.

AB - The photodynamic activity of water soluble mixed sulfonated metallophthalocyanines complexes: GePcSmix, SnPcSmix and SiPcSmix on human oesophageal carcinoma (SNO) cells are reported, and compared with the activity of the unmetallated H2PcSmix and of the newly synthesized water soluble adjacently substituted binaphthalo phthalocyanine (complex 3). The alkaline phosphate (ALP) showed damage to the cell membrane in the presence of complex 3 without irradiation. The GePcSmix complex caused a relatively large increase in inflammation and a high intracellular ATP.

KW - Cell proliferation

KW - Cell viability

KW - Germanium

KW - Phthalocyanine

KW - Silicon

KW - Tin

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AN - SCOPUS:33644858859

SN - 1011-1344

VL - 83

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JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

IS - 1

ER -

The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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