The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

Eloise Ferreira; Appollinaire Munyaneza; Bernard Omondi; Reinout Meijboom; Marianne J. Cronjé

doi:10.1007/s10534-015-9865-5

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

Eloise Ferreira, Appollinaire Munyaneza, Bernard Omondi, Reinout Meijboom, Marianne J. Cronjé

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

There is much interest currently in the design of metal compounds as drugs and various metal compounds are already in clinical use. These include gold(I) compounds such as auranofin and the anti-cancer platinum(II) complex, cisplatin. Bis-chelated gold(I) phosphine complexes have also shown great potential as anticancer agents, however, their efficacy has been limited by their high toxicity. In this study, silver(I) thiocyanate compounds linked to four specific ligands, were synthesized and characterized. These silver-phosphine adducts included [AgSCN{P(4-MeC₆H₄)₃}₂]₂ (1); [AgSCN{P(4-ClC₆H₄)₃}₂]₂ (2); [AgSCN{P(4-MeOC₆H₄)₃}₂]₂ (3); [AgSCN(PPh₃)₂]₂ (4). The compounds were found to be toxic to MCF-7 breast cancer cells while the ligands on their own were not toxic. Our findings further indicate that the silver(I) phosphine compounds induce apoptotic cell death in these breast cancer cells. In addition, the compounds were not toxic to nonmalignant fibroblast cells at the IC50 concentrations. This is an indication that the compounds show selectivity towards the cancer cells.

Original language	English
Pages (from-to)	765-781
Number of pages	17
Journal	BioMetals
Volume	28
Issue number	4
DOIs	https://doi.org/10.1007/s10534-015-9865-5
Publication status	Published - 27 Aug 2015

Keywords

Anti-cancer
Apoptosis
Drug discovery
Flow-cytometry
MCF-7 breast cancer cells
Silver-phosphine complexes

ASJC Scopus subject areas

Biomaterials
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences
Metals and Alloys

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10534-015-9865-5

Cite this

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title = "The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells",

abstract = "There is much interest currently in the design of metal compounds as drugs and various metal compounds are already in clinical use. These include gold(I) compounds such as auranofin and the anti-cancer platinum(II) complex, cisplatin. Bis-chelated gold(I) phosphine complexes have also shown great potential as anticancer agents, however, their efficacy has been limited by their high toxicity. In this study, silver(I) thiocyanate compounds linked to four specific ligands, were synthesized and characterized. These silver-phosphine adducts included [AgSCN{P(4-MeC6H4)3}2]2 (1); [AgSCN{P(4-ClC6H4)3}2]2 (2); [AgSCN{P(4-MeOC6H4)3}2]2 (3); [AgSCN(PPh3)2]2 (4). The compounds were found to be toxic to MCF-7 breast cancer cells while the ligands on their own were not toxic. Our findings further indicate that the silver(I) phosphine compounds induce apoptotic cell death in these breast cancer cells. In addition, the compounds were not toxic to nonmalignant fibroblast cells at the IC50 concentrations. This is an indication that the compounds show selectivity towards the cancer cells.",

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AU - Cronjé, Marianne J.

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AB - There is much interest currently in the design of metal compounds as drugs and various metal compounds are already in clinical use. These include gold(I) compounds such as auranofin and the anti-cancer platinum(II) complex, cisplatin. Bis-chelated gold(I) phosphine complexes have also shown great potential as anticancer agents, however, their efficacy has been limited by their high toxicity. In this study, silver(I) thiocyanate compounds linked to four specific ligands, were synthesized and characterized. These silver-phosphine adducts included [AgSCN{P(4-MeC6H4)3}2]2 (1); [AgSCN{P(4-ClC6H4)3}2]2 (2); [AgSCN{P(4-MeOC6H4)3}2]2 (3); [AgSCN(PPh3)2]2 (4). The compounds were found to be toxic to MCF-7 breast cancer cells while the ligands on their own were not toxic. Our findings further indicate that the silver(I) phosphine compounds induce apoptotic cell death in these breast cancer cells. In addition, the compounds were not toxic to nonmalignant fibroblast cells at the IC50 concentrations. This is an indication that the compounds show selectivity towards the cancer cells.

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The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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