The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

Eloise Ferreira, Appollinaire Munyaneza, Bernard Omondi, Reinout Meijboom, Marianne J. Cronjé

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

There is much interest currently in the design of metal compounds as drugs and various metal compounds are already in clinical use. These include gold(I) compounds such as auranofin and the anti-cancer platinum(II) complex, cisplatin. Bis-chelated gold(I) phosphine complexes have also shown great potential as anticancer agents, however, their efficacy has been limited by their high toxicity. In this study, silver(I) thiocyanate compounds linked to four specific ligands, were synthesized and characterized. These silver-phosphine adducts included [AgSCN{P(4-MeC6H4)3}2]2 (1); [AgSCN{P(4-ClC6H4)3}2]2 (2); [AgSCN{P(4-MeOC6H4)3}2]2 (3); [AgSCN(PPh3)2]2 (4). The compounds were found to be toxic to MCF-7 breast cancer cells while the ligands on their own were not toxic. Our findings further indicate that the silver(I) phosphine compounds induce apoptotic cell death in these breast cancer cells. In addition, the compounds were not toxic to nonmalignant fibroblast cells at the IC50 concentrations. This is an indication that the compounds show selectivity towards the cancer cells.

Original languageEnglish
Pages (from-to)765-781
Number of pages17
JournalBioMetals
Volume28
Issue number4
DOIs
Publication statusPublished - 27 Aug 2015

Keywords

  • Anti-cancer
  • Apoptosis
  • Drug discovery
  • Flow-cytometry
  • MCF-7 breast cancer cells
  • Silver-phosphine complexes

ASJC Scopus subject areas

  • Biomaterials
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Metals and Alloys

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