TY - JOUR
T1 - The dual role of chaperone-mediated autophagy in the response and resistance to cancer immunotherapy
AU - Saberiyan, Mohammadreza
AU - Gholami, Sarah
AU - Ejlalidiz, Mahsa
AU - Rezaeian Manshadi, Mohammadsadegh
AU - Noorabadi, parisa
AU - Hamblin, Michael R.
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/6
Y1 - 2025/6
N2 - Cancer immunotherapy has become a revolutionary strategy in oncology, utilizing the host immune system to fight malignancies. Notwithstanding major progress, obstacles such as immune evasion by tumors and the development of resistance still remain. This manuscript examines the function of chaperone-mediated autophagy (CMA) in cancer biology, focusing on its effects on tumor immunotherapy response and resistance. CMA is a selective degradation mechanism for cytosolic proteins, which is crucial for sustaining cellular homeostasis and regulating immune responses. By degrading specific proteins, CMA can either facilitate tumor progression in stressful conditions, or promote tumor suppression by removing oncogenic factors. This double-edged sword highlights the complexity of CMA in cancer progression and its possible effect on treatment results. Here we clarify the molecular mechanisms by which CMA can regulate the immune response and its possible role as a therapeutic target for improving the effectiveness of cancer immunotherapy.
AB - Cancer immunotherapy has become a revolutionary strategy in oncology, utilizing the host immune system to fight malignancies. Notwithstanding major progress, obstacles such as immune evasion by tumors and the development of resistance still remain. This manuscript examines the function of chaperone-mediated autophagy (CMA) in cancer biology, focusing on its effects on tumor immunotherapy response and resistance. CMA is a selective degradation mechanism for cytosolic proteins, which is crucial for sustaining cellular homeostasis and regulating immune responses. By degrading specific proteins, CMA can either facilitate tumor progression in stressful conditions, or promote tumor suppression by removing oncogenic factors. This double-edged sword highlights the complexity of CMA in cancer progression and its possible effect on treatment results. Here we clarify the molecular mechanisms by which CMA can regulate the immune response and its possible role as a therapeutic target for improving the effectiveness of cancer immunotherapy.
KW - (cGAS)-STING pathway
KW - Immune checkpoint inhibitors
KW - Immune evasion
KW - Resistance mechanisms
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=105000034799&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2025.104700
DO - 10.1016/j.critrevonc.2025.104700
M3 - Review article
AN - SCOPUS:105000034799
SN - 1040-8428
VL - 210
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 104700
ER -