TY - JOUR
T1 - The chiral synthesis of thiazole amino acid enantiomers
AU - Bredenkamp, Martin W.
AU - Holzapfel, Cedric W.
AU - van Zyl, Wynand J.
PY - 1990/8/1
Y1 - 1990/8/1
N2 - An efficient modified Hantzsch reaction is described for the synthesis of optically pure thiazole amino acid derivatives from the corresponding amino acids. The method is exemplified by the synthesis of a derivative of L-(Gln)Thz, the novel chiral thiazole amino acid moiety of dolastatin 3, The Cotton effects of thiazole amino acids correlate well with the absolute stereochemistry of these compounds.
AB - An efficient modified Hantzsch reaction is described for the synthesis of optically pure thiazole amino acid derivatives from the corresponding amino acids. The method is exemplified by the synthesis of a derivative of L-(Gln)Thz, the novel chiral thiazole amino acid moiety of dolastatin 3, The Cotton effects of thiazole amino acids correlate well with the absolute stereochemistry of these compounds.
UR - http://www.scopus.com/inward/record.url?scp=84973069306&partnerID=8YFLogxK
U2 - 10.1080/00397919008053164
DO - 10.1080/00397919008053164
M3 - Article
AN - SCOPUS:84973069306
SN - 0039-7911
VL - 20
SP - 2235
EP - 2249
JO - Synthetic Communications
JF - Synthetic Communications
IS - 15
ER -