The biosynthesis of showdomycin: Studies with stable isotopes and the determination of principal precursors

J. Grant Buchanan; Michael R. Hamblin; Ajit Kumar; Richard H. Wightman

doi:10.1039/c39840001515

The biosynthesis of showdomycin: Studies with stable isotopes and the determination of principal precursors

J. Grant Buchanan, Michael R. Hamblin, Ajit Kumar, Richard H. Wightman

Heriot-Watt University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Studies with stable isotopes show that D-ribose and L-glutamic acid are direct biosynthetic precursors of showdomycin (1), with carbons 2-5 and the nitrogen of L-glutamate giving rise to the maleimide ring: L-pyroglutamate may be an intermediate.

Original language	English
Pages (from-to)	1515-1517
Number of pages	3
Journal	Chemical Communications
Issue number	22
DOIs	https://doi.org/10.1039/c39840001515
Publication status	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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title = "The biosynthesis of showdomycin: Studies with stable isotopes and the determination of principal precursors",

abstract = "Studies with stable isotopes show that D-ribose and L-glutamic acid are direct biosynthetic precursors of showdomycin (1), with carbons 2-5 and the nitrogen of L-glutamate giving rise to the maleimide ring: L-pyroglutamate may be an intermediate.",

author = "Buchanan, \{J. Grant\} and Hamblin, \{Michael R.\} and Ajit Kumar and Wightman, \{Richard H.\}",

year = "1984",

doi = "10.1039/c39840001515",

language = "English",

pages = "1515--1517",

journal = "Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

number = "22",

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T1 - The biosynthesis of showdomycin

T2 - Studies with stable isotopes and the determination of principal precursors

AU - Buchanan, J. Grant

AU - Hamblin, Michael R.

AU - Kumar, Ajit

AU - Wightman, Richard H.

PY - 1984

Y1 - 1984

N2 - Studies with stable isotopes show that D-ribose and L-glutamic acid are direct biosynthetic precursors of showdomycin (1), with carbons 2-5 and the nitrogen of L-glutamate giving rise to the maleimide ring: L-pyroglutamate may be an intermediate.

AB - Studies with stable isotopes show that D-ribose and L-glutamic acid are direct biosynthetic precursors of showdomycin (1), with carbons 2-5 and the nitrogen of L-glutamate giving rise to the maleimide ring: L-pyroglutamate may be an intermediate.

UR - https://www.scopus.com/pages/publications/0021747653

U2 - 10.1039/c39840001515

DO - 10.1039/c39840001515

M3 - Article

AN - SCOPUS:0021747653

SN - 0022-4936

SP - 1515

EP - 1517

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

The biosynthesis of showdomycin: Studies with stable isotopes and the determination of principal precursors

Abstract

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