TGF-β and WNT signaling pathways in cardiac fibrosis: Non-coding RNAs come into focus

Fatemeh Yousefi, Zahra Shabaninejad, Sina Vakili, Maryam Derakhshan, Ahmad Movahedpour, Hamed Dabiri, Younes Ghasemi, Maryam Mahjoubin-Tehran, Azin Nikoozadeh, Amir Savardashtaki, Hamed Mirzaei, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

110 Citations (Scopus)


Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found in many pathophysiological heart conditions. A range of molecular components and cellular pathways, have been implicated in its pathogenesis. In this review, we focus on the TGF-β and WNT signaling pathways, and their mutual interaction, which have emerged as important factors involved in cardiac pathophysiology. The molecular and cellular processes involved in the initiation and progression of cardiac fibrosis are summarized. We focus on TGF-β and WNT signaling in cardiac fibrosis, ECM production, and myofibroblast transformation. Non-coding RNAs (ncRNAs) are one of the main players in the regulation of multiple pathways and cellular processes. MicroRNAs, long non-coding RNAs, and circular long non-coding RNAs can all interact with the TGF-β/WNT signaling axis to affect cardiac fibrosis. A better understanding of these processes may lead to new approaches for diagnosis and treatment of many cardiac conditions. [MediaObject not available: see fulltext.]

Original languageEnglish
Article number87
JournalCell Communication and Signaling
Issue number1
Publication statusPublished - 9 Jun 2020


  • Cardiac fibrosis
  • Non-coding RNAs
  • TGF-β/WNT signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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