Targeting the metabolism of cancer stem cells by energy disruptor molecules

Tahere Dadgar, Nasim Ebrahimi, Amir Reza Gholipour, Maryam Akbari, Leila Khani, Amirhossein Ahmadi, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Cancer stem cells (CSCs) have been identified in various tumor types. CSCs are believed to contribute to tumor metastasis and resistance to conventional therapy. So targeting these cells could be an effective strategy to eliminate tumors and a promising new type of cancer treatment. Alterations in metabolism play an essential role in CSC biology and their resistance to treatment. The metabolic properties pathways in CSCs are different from normal cells, and to some extent, are different from regular tumor cells. Interestingly, CSCs can use other nutrients for their metabolism and growth. The different metabolism causes increased sensitivity of CSCs to agents that disrupt cellular homeostasis. Compounds that interfere with the central metabolic pathways are known as energy disruptors and can reduce CSC survival. This review highlights the differences between regular cancer cells and CSC metabolism and discusses the action mechanisms of energy disruptors at the cellular and molecular levels.

Original languageEnglish
Article number103545
JournalCritical Reviews in Oncology/Hematology
Publication statusPublished - Jan 2022


  • Cancer
  • Cancer stem cells
  • Energy disruptors
  • Metabolism

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology


Dive into the research topics of 'Targeting the metabolism of cancer stem cells by energy disruptor molecules'. Together they form a unique fingerprint.

Cite this