System dynamics of active and passive postural changes: Insights from principal dynamic modes analysis of baroreflex loop

Tariq Shahzad, Saqib Saleem, Saeeda Usman, Jawad Mirza, Qamar ul Islam, Khmaies Ouahada, Tshilidzi Marwala

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The baroreflex being a key modulator of cardiovascular control ensures adequate blood pressure regulation under orthostatic stress which otherwise may cause severe hypotension. Contrary to conventional baroreflex sensitivity indices derived across a-priori traditional frequency bands, the present study is aimed at proposing new indices for the assessment of baroreflex drive which follows active (supine to stand-up) and passive (supine to head-up tilt) postural changes. To achieve this, a novel system identification approach of principal dynamic modes (PDM) was utilized to extract data-adaptive frequency components of closed-loop interactions between beat-to-beat interval and systolic blood pressure recorded from 10 healthy humans. We observed that the gain of low-pass global PDM of cardiac arm (:feedback reflex loop, mediated by pressure sensors to adjust heart rate in response to arterial blood pressure), and 0.2 Hz global PDM of mechanical arm (:feed-forward pathways, originating changes in arterial blood pressure in response to heart rate variations) may function as potential markers to distinguish active and passive orthostatic tests in healthy subjects.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalComputers in Biology and Medicine
Volume100
DOIs
Publication statusPublished - 1 Sept 2018

Keywords

  • Associated nonlinear function
  • Baroreflex
  • Blood pressure
  • Cardiac arm
  • Mechanical arm
  • Principal dynamic modes
  • R-R interval

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications

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