Synthetic approach to biotinylated glyco-functionalized quantum dots: A new fluorescent probes for biomedical applications

Christian K. Adokoh, James Darkwa, Ravin Narain

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Technological advances that allow deeper penetration in live tissues, such as the development of confocal and the generation of ever-new fluorophores that facilitate bright labeling of cells and tissue components have made imaging of vertebrate model organisms efficient and highly informative. Recently, high luminescence, single-excitation narrow emission, low photo bleaching properties, and low toxicity of high- quality water-soluble QDs have attracted attention for in vivo labeling/imaging of cells. Herein we describe a synthetic approach to biotinylated glycopolymer functionalized quantum dots, with special emphasis on the development of high-quality water-soluble and bioactive QDs with low toxicity for fluorescent probes in biomedical applications.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages109-121
Number of pages13
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1367
ISSN (Print)1064-3745

Keywords

  • Biotin
  • Biotinylated glycopolymers
  • Fluorescent probes
  • Quantum dots

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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