Synthesis, optical, structural and biocompatibility assessment of red-emitting CuInS2-ZnS quantum dots conjugated to folic acid

Sundararajan Parani; Oluwatobi S. Oluwafemi

doi:10.1016/j.nanoso.2022.100916

Synthesis, optical, structural and biocompatibility assessment of red-emitting CuInS₂-ZnS quantum dots conjugated to folic acid

Sundararajan Parani, Oluwatobi S. Oluwafemi

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Bioconjugation of nanoparticles is a hot topic of research for a wide range of biological applications, particularly in cancer diagnosis and treatment. In this study, we report the synthesis of glutathione capped CuInS₂/ZnS quantum dots (QDs) in an aqueous medium followed by folic acid (FA) modification to produce CIS-ZnS/FA conjugates. The as-synthesized QDs were small, with an average particle diameter of 2.3 nm, and emit in the red region, which was retained even after conjugation with FA. The formation of the conjugates was investigated by ultraviolet–visible (UV–Vis) absorption, photoluminescence (PL) and Fourier transform infrared (FTIR) spectroscopy. The conjugate were then analyzed for their cytotoxicity against both folate receptor (FR) positive (HeLa) and FR negative (A549, C26) cancer cell lines. The results of this study revealed the highly biocompatible nature of the CIS-ZnS/FA conjugates towards both FR positive and negative cancer cell lines and thus they are of potential use in biological applications.

Original language	English
Article number	100916
Journal	Nano-Structures and Nano-Objects
Volume	32
DOIs	https://doi.org/10.1016/j.nanoso.2022.100916
Publication status	Published - Oct 2022

Keywords

Cell viability
Conjugation
CuInS/ZnS
Folic acid
Quantum dots
Ternary

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
General Materials Science
Condensed Matter Physics
Physical and Theoretical Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nanoso.2022.100916

Cite this

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title = "Synthesis, optical, structural and biocompatibility assessment of red-emitting CuInS2-ZnS quantum dots conjugated to folic acid",

abstract = "Bioconjugation of nanoparticles is a hot topic of research for a wide range of biological applications, particularly in cancer diagnosis and treatment. In this study, we report the synthesis of glutathione capped CuInS2/ZnS quantum dots (QDs) in an aqueous medium followed by folic acid (FA) modification to produce CIS-ZnS/FA conjugates. The as-synthesized QDs were small, with an average particle diameter of 2.3 nm, and emit in the red region, which was retained even after conjugation with FA. The formation of the conjugates was investigated by ultraviolet–visible (UV–Vis) absorption, photoluminescence (PL) and Fourier transform infrared (FTIR) spectroscopy. The conjugate were then analyzed for their cytotoxicity against both folate receptor (FR) positive (HeLa) and FR negative (A549, C26) cancer cell lines. The results of this study revealed the highly biocompatible nature of the CIS-ZnS/FA conjugates towards both FR positive and negative cancer cell lines and thus they are of potential use in biological applications.",

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AU - Parani, Sundararajan

AU - Oluwafemi, Oluwatobi S.

PY - 2022/10

Y1 - 2022/10

N2 - Bioconjugation of nanoparticles is a hot topic of research for a wide range of biological applications, particularly in cancer diagnosis and treatment. In this study, we report the synthesis of glutathione capped CuInS2/ZnS quantum dots (QDs) in an aqueous medium followed by folic acid (FA) modification to produce CIS-ZnS/FA conjugates. The as-synthesized QDs were small, with an average particle diameter of 2.3 nm, and emit in the red region, which was retained even after conjugation with FA. The formation of the conjugates was investigated by ultraviolet–visible (UV–Vis) absorption, photoluminescence (PL) and Fourier transform infrared (FTIR) spectroscopy. The conjugate were then analyzed for their cytotoxicity against both folate receptor (FR) positive (HeLa) and FR negative (A549, C26) cancer cell lines. The results of this study revealed the highly biocompatible nature of the CIS-ZnS/FA conjugates towards both FR positive and negative cancer cell lines and thus they are of potential use in biological applications.

AB - Bioconjugation of nanoparticles is a hot topic of research for a wide range of biological applications, particularly in cancer diagnosis and treatment. In this study, we report the synthesis of glutathione capped CuInS2/ZnS quantum dots (QDs) in an aqueous medium followed by folic acid (FA) modification to produce CIS-ZnS/FA conjugates. The as-synthesized QDs were small, with an average particle diameter of 2.3 nm, and emit in the red region, which was retained even after conjugation with FA. The formation of the conjugates was investigated by ultraviolet–visible (UV–Vis) absorption, photoluminescence (PL) and Fourier transform infrared (FTIR) spectroscopy. The conjugate were then analyzed for their cytotoxicity against both folate receptor (FR) positive (HeLa) and FR negative (A549, C26) cancer cell lines. The results of this study revealed the highly biocompatible nature of the CIS-ZnS/FA conjugates towards both FR positive and negative cancer cell lines and thus they are of potential use in biological applications.

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