Synthesis of photoresponsive dual NIR two-photon absorptive [60]fullerene triads and tetrads

Seaho Jeon; Min Wang; Loon Seng Tan; Thomas Cooper; Michael R. Hamblin; Long Y. Chiang

doi:10.3390/molecules18089603

Synthesis of photoresponsive dual NIR two-photon absorptive [60]fullerene triads and tetrads

Seaho Jeon, Min Wang, Loon Seng Tan, Thomas Cooper, Michael R. Hamblin, Long Y. Chiang

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Broadband nonlinear optical (NLO) organic nanostructures exhibiting both ultrafast photoresponse and a large cross-section of two-photon absorption throughout a wide NIR spectrum may make them suitable for use as nonlinear biophotonic materials. We report here the synthesis and characterization of two C₆₀-(antenna)_x analogous compounds as branched triad C₆₀ (>DPAF-C₁₈)(>CPAF-C_2M) and tetrad C₆₀(>DPAF-C₁₈)(>CPAF-C_2M)₂ nanostructures. These compounds showed approximately equal extinction coefficients of optical absorption over 400-550 nm that corresponds to near-IR two-photon based excitation wavelengths at 780-1,100 nm. Accordingly, they may be utilized as potential precursor candidates to the active-core structures of photosensitizing nanodrugs for 2γ-PDT in the biological optical window of 800-1,050 nm.

Original language	English
Pages (from-to)	9603-9622
Number of pages	20
Journal	Molecules
Volume	18
Issue number	8
DOIs	https://doi.org/10.3390/molecules18089603
Publication status	Published - Aug 2013
Externally published	Yes

Keywords

2γ-photodynamic therapeutic agent
C-(antenna) nanostructures
NIR two-photon absorption
Photosensitizer
Ultrafast intramolecular energy-transfer

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis of photoresponsive dual NIR two-photon absorptive [60]fullerene triads and tetrads",

abstract = "Broadband nonlinear optical (NLO) organic nanostructures exhibiting both ultrafast photoresponse and a large cross-section of two-photon absorption throughout a wide NIR spectrum may make them suitable for use as nonlinear biophotonic materials. We report here the synthesis and characterization of two C60-(antenna)x analogous compounds as branched triad C60 (>DPAF-C18)(>CPAF-C2M) and tetrad C60(>DPAF-C18)(>CPAF-C2M)2 nanostructures. These compounds showed approximately equal extinction coefficients of optical absorption over 400-550 nm that corresponds to near-IR two-photon based excitation wavelengths at 780-1,100 nm. Accordingly, they may be utilized as potential precursor candidates to the active-core structures of photosensitizing nanodrugs for 2γ-PDT in the biological optical window of 800-1,050 nm.",

keywords = "2γ-photodynamic therapeutic agent, C-(antenna) nanostructures, NIR two-photon absorption, Photosensitizer, Ultrafast intramolecular energy-transfer",

author = "Seaho Jeon and Min Wang and Tan, {Loon Seng} and Thomas Cooper and Hamblin, {Michael R.} and Chiang, {Long Y.}",

year = "2013",

month = aug,

doi = "10.3390/molecules18089603",

language = "English",

volume = "18",

pages = "9603--9622",

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T1 - Synthesis of photoresponsive dual NIR two-photon absorptive [60]fullerene triads and tetrads

AU - Jeon, Seaho

AU - Wang, Min

AU - Tan, Loon Seng

AU - Cooper, Thomas

AU - Hamblin, Michael R.

AU - Chiang, Long Y.

PY - 2013/8

Y1 - 2013/8

N2 - Broadband nonlinear optical (NLO) organic nanostructures exhibiting both ultrafast photoresponse and a large cross-section of two-photon absorption throughout a wide NIR spectrum may make them suitable for use as nonlinear biophotonic materials. We report here the synthesis and characterization of two C60-(antenna)x analogous compounds as branched triad C60 (>DPAF-C18)(>CPAF-C2M) and tetrad C60(>DPAF-C18)(>CPAF-C2M)2 nanostructures. These compounds showed approximately equal extinction coefficients of optical absorption over 400-550 nm that corresponds to near-IR two-photon based excitation wavelengths at 780-1,100 nm. Accordingly, they may be utilized as potential precursor candidates to the active-core structures of photosensitizing nanodrugs for 2γ-PDT in the biological optical window of 800-1,050 nm.

AB - Broadband nonlinear optical (NLO) organic nanostructures exhibiting both ultrafast photoresponse and a large cross-section of two-photon absorption throughout a wide NIR spectrum may make them suitable for use as nonlinear biophotonic materials. We report here the synthesis and characterization of two C60-(antenna)x analogous compounds as branched triad C60 (>DPAF-C18)(>CPAF-C2M) and tetrad C60(>DPAF-C18)(>CPAF-C2M)2 nanostructures. These compounds showed approximately equal extinction coefficients of optical absorption over 400-550 nm that corresponds to near-IR two-photon based excitation wavelengths at 780-1,100 nm. Accordingly, they may be utilized as potential precursor candidates to the active-core structures of photosensitizing nanodrugs for 2γ-PDT in the biological optical window of 800-1,050 nm.

KW - 2γ-photodynamic therapeutic agent

KW - C-(antenna) nanostructures

KW - NIR two-photon absorption

KW - Photosensitizer

KW - Ultrafast intramolecular energy-transfer

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U2 - 10.3390/molecules18089603

DO - 10.3390/molecules18089603

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SN - 1420-3049

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JO - Molecules

JF - Molecules

IS - 8

ER -

Synthesis of photoresponsive dual NIR two-photon absorptive [60]fullerene triads and tetrads

Abstract

Keywords

ASJC Scopus subject areas

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