Synthesis of fluorescent CuInS2/ZnS quantum dots - Porphyrin conjugates for photodynamic therapy

Ncediwe Tsolekile; Vuyelwa Ncapayi; Sundararajan Parani; El Hadji Mamour Sakho; Mangaka C. Matoetoe; Sandile P. Songca; Oluwatobi S. Oluwafemi

doi:10.1557/mrc.2018.60

Synthesis of fluorescent CuInS₂/ZnS quantum dots - Porphyrin conjugates for photodynamic therapy

Ncediwe Tsolekile
, Vuyelwa Ncapayi
, Sundararajan Parani
, El Hadji Mamour Sakho
, Mangaka C. Matoetoe
, Sandile P. Songca
, Oluwatobi S. Oluwafemi

Chemical Sciences

University of Johannesburg
Cape Peninsula University of Technology
University of Zululand

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.

Original language	English
Pages (from-to)	398-403
Number of pages	6
Journal	MRS Communications
Volume	8
Issue number	2
DOIs	https://doi.org/10.1557/mrc.2018.60
Publication status	Published - 1 Jun 2018

ASJC Scopus subject areas

General Materials Science

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10.1557/mrc.2018.60

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title = "Synthesis of fluorescent CuInS2/ZnS quantum dots - Porphyrin conjugates for photodynamic therapy",

abstract = "Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.",

author = "Ncediwe Tsolekile and Vuyelwa Ncapayi and Sundararajan Parani and Sakho, \{El Hadji Mamour\} and Matoetoe, \{Mangaka C.\} and Songca, \{Sandile P.\} and Oluwafemi, \{Oluwatobi S.\}",

note = "Publisher Copyright: {\textcopyright} Copyright Materials Research Society 2018.",

year = "2018",

month = jun,

day = "1",

doi = "10.1557/mrc.2018.60",

language = "English",

volume = "8",

pages = "398--403",

journal = "MRS Communications",

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publisher = "Springer International Publishing AG",

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T1 - Synthesis of fluorescent CuInS2/ZnS quantum dots - Porphyrin conjugates for photodynamic therapy

AU - Tsolekile, Ncediwe

AU - Ncapayi, Vuyelwa

AU - Parani, Sundararajan

AU - Sakho, El Hadji Mamour

AU - Matoetoe, Mangaka C.

AU - Songca, Sandile P.

AU - Oluwafemi, Oluwatobi S.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.

AB - Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.

UR - https://www.scopus.com/pages/publications/85045645754

U2 - 10.1557/mrc.2018.60

DO - 10.1557/mrc.2018.60

M3 - Article

AN - SCOPUS:85045645754

SN - 2159-6859

VL - 8

SP - 398

EP - 403

JO - MRS Communications

JF - MRS Communications

IS - 2

ER -

Synthesis of fluorescent CuInS₂/ZnS quantum dots - Porphyrin conjugates for photodynamic therapy

Abstract

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