TY - JOUR
T1 - Synthesis of fluorescent CuInS2/ZnS quantum dots - Porphyrin conjugates for photodynamic therapy
AU - Tsolekile, Ncediwe
AU - Ncapayi, Vuyelwa
AU - Parani, Sundararajan
AU - Sakho, El Hadji Mamour
AU - Matoetoe, Mangaka C.
AU - Songca, Sandile P.
AU - Oluwafemi, Oluwatobi S.
N1 - Publisher Copyright:
© Copyright Materials Research Society 2018.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.
AB - Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.
UR - http://www.scopus.com/inward/record.url?scp=85045645754&partnerID=8YFLogxK
U2 - 10.1557/mrc.2018.60
DO - 10.1557/mrc.2018.60
M3 - Article
AN - SCOPUS:85045645754
SN - 2159-6859
VL - 8
SP - 398
EP - 403
JO - MRS Communications
JF - MRS Communications
IS - 2
ER -