Synthesis, crystal structure and spectral studies of silver(I) cyclohexyldiphenylphosphine complexes: towards the biological evaluation on malignant and non-malignant cells

Gadada Naganagowda, Zelinda Engelbrecht, Kariska Potgieter, Frederick P. Malan, Phendukani Ncube, Marianne J. Cronjé, Reinout Meijboom

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cancer is a fast-growing disease responsible for many deaths worldwide. Due to its aggressive and forever-changing nature, it is imperative to find alternative anti-cancer agents that could possibly treat this disease. Silver(I) phosphine complexes were synthesized by reaction of AgNO3, AgCl, and AgBr with cyclohexyldiphenylphosphine to produce 1:1, 1:2, or 1:3 molar ratios of new silver complexes with the formulas [Ag(PPh2Cy)NO3] (1), [Ag(PPh2Cy)2NO3] (2), [Ag(PPh2Cy)3NO3] (3), [Ag(PPh2Cy)2Cl] (4), [Ag(PPh2Cy)3Cl] (5), and [Ag(PPh2Cy)3Br] (6), respectively. The complexes were characterized by elemental analyses, FT-IR and 1H, 13C, 31P NMR spectroscopic techniques. The crystal structures of 5 (CCDC 1480482) and 6 (CCDC 2183297) were determined by single-crystal X-ray diffractometry. All six complexes were evaluated as potential anti-cancer agents in four different human malignant (SNO, MCF-7, A375, and A549) cell lines and one human non-malignant (HEK293) cell line. Overall, these complexes were significantly cytotoxic to both cancerous and non-cancerous cells and are therefore not considered suitable anti-cancer agents in their current form.

Original languageEnglish
Pages (from-to)45-60
Number of pages16
JournalJournal of Coordination Chemistry
Volume76
Issue number1
DOIs
Publication statusPublished - 2023

Keywords

  • Silver(I) complexes
  • anti-cancer activity
  • crystal structure
  • cyclohexyldiphenylphosphine
  • cytotoxicity

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry

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