Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug

A. S. Ndamase, B. A. Aderibigbe, E. R. Sadiku, P. Labuschagne, Y. Lemmer, S. S. Ray, M. Nwamadi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Bisphosphonates have been found to be effective when combined with anticancer drugs for chemotherapy. In this paper, pamidronate and platinum complexes were conjugated to linear poly(amidoamine)s (PAMAM) to improve the drug efficacy. The conjugates were synthesized by aqueous phase Michael-addition polymerization reaction and characterized using SEM, TEM, XRD, FTIR, NMR and EDS to confirm successful conjugation of the drug to the polymeric carrier. In vitro cytotoxicity assays were performed against HeLa cell lines. FTIR, NMR and EDS confirmed the conjugation of the drugs to the polymer, and viability assay confirmed that the conjugates were not as toxic as the free drugs to the cells. The results obtained suggest that PAMAM are potential drug delivery devices for anticancer drugs with enhanced therapeutic effects. However, further characterization and in vitro tests will need to be conducted before further steps are taken.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalJournal of Drug Delivery Science and Technology
Volume43
DOIs
Publication statusPublished - Feb 2018
Externally publishedYes

Keywords

  • Anticancer
  • Breast cancer
  • Combination therapy
  • Polyamidoamine
  • Polymer-drug conjugates

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug'. Together they form a unique fingerprint.

Cite this