TY - JOUR
T1 - Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde
AU - Ikhile, Monisola Itohan
AU - Fotsing, Marthe Carine Djuidje
AU - Arderne, Charmaine
AU - Ngila, Jane Catherine
AU - Ndinteh, Derek Tantoh
N1 - Publisher Copyright:
© 2017 Journal of Chinese Pharmaceutical Sciences.
PY - 2017/12/27
Y1 - 2017/12/27
N2 - Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1-4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P21/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.
AB - Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1-4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P21/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.
KW - Biological activity
KW - Schiff bases
KW - Synthesis
KW - X-ray diffraction characterization
UR - http://www.scopus.com/inward/record.url?scp=85044097335&partnerID=8YFLogxK
U2 - 10.5246/jcps.2017.12.096
DO - 10.5246/jcps.2017.12.096
M3 - Article
AN - SCOPUS:85044097335
SN - 1003-1057
VL - 26
SP - 858
EP - 871
JO - Journal of Chinese Pharmaceutical Sciences
JF - Journal of Chinese Pharmaceutical Sciences
IS - 12
ER -
