Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

Haleden Chiririwa; John R. Moss; Denver Hendricks; Gregory S. Smith; Reinout Meijboom

doi:10.1016/j.poly.2012.09.053

Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

Haleden Chiririwa
, John R. Moss
, Denver Hendricks
, Gregory S. Smith
, Reinout Meijboom

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The reactions of iminophosphine ligands with [PtCl₂(COD)], [PtCl₂(DMSO)₂], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (¹H and ³¹P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC₅₀ range of 2.16-9.47 μM.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	Polyhedron
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.poly.2012.09.053
Publication status	Published - 25 Jan 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer
Gold(I) complexes
Iminophosphines
Platinum(II) complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.poly.2012.09.053

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title = "Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity",

abstract = "The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM.",

keywords = "Anticancer, Gold(I) complexes, Iminophosphines, Platinum(II) complexes",

author = "Haleden Chiririwa and Moss, \{John R.\} and Denver Hendricks and Smith, \{Gregory S.\} and Reinout Meijboom",

year = "2013",

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doi = "10.1016/j.poly.2012.09.053",

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T1 - Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

AU - Chiririwa, Haleden

AU - Moss, John R.

AU - Hendricks, Denver

AU - Smith, Gregory S.

AU - Meijboom, Reinout

PY - 2013/1/25

Y1 - 2013/1/25

N2 - The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM.

AB - The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM.

KW - Anticancer

KW - Gold(I) complexes

KW - Iminophosphines

KW - Platinum(II) complexes

UR - https://www.scopus.com/pages/publications/84868249509

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DO - 10.1016/j.poly.2012.09.053

M3 - Article

AN - SCOPUS:84868249509

SN - 0277-5387

VL - 49

SP - 29

EP - 35

JO - Polyhedron

JF - Polyhedron

IS - 1

ER -

Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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