Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

Haleden Chiririwa; John R. Moss; Denver Hendricks; Gregory S. Smith; Reinout Meijboom

doi:10.1016/j.poly.2012.09.053

Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

Haleden Chiririwa, John R. Moss, Denver Hendricks, Gregory S. Smith, Reinout Meijboom

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The reactions of iminophosphine ligands with [PtCl₂(COD)], [PtCl₂(DMSO)₂], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (¹H and ³¹P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC₅₀ range of 2.16-9.47 μM.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	Polyhedron
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.poly.2012.09.053
Publication status	Published - 25 Jan 2013

Keywords

Anticancer
Gold(I) complexes
Iminophosphines
Platinum(II) complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.poly.2012.09.053

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title = "Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity",

abstract = "The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM.",

keywords = "Anticancer, Gold(I) complexes, Iminophosphines, Platinum(II) complexes",

author = "Haleden Chiririwa and Moss, {John R.} and Denver Hendricks and Smith, {Gregory S.} and Reinout Meijboom",

year = "2013",

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T1 - Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

AU - Chiririwa, Haleden

AU - Moss, John R.

AU - Hendricks, Denver

AU - Smith, Gregory S.

AU - Meijboom, Reinout

PY - 2013/1/25

Y1 - 2013/1/25

N2 - The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM.

AB - The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM.

KW - Anticancer

KW - Gold(I) complexes

KW - Iminophosphines

KW - Platinum(II) complexes

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DO - 10.1016/j.poly.2012.09.053

M3 - Article

AN - SCOPUS:84868249509

SN - 0277-5387

VL - 49

SP - 29

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JO - Polyhedron

JF - Polyhedron

IS - 1

ER -

Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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