Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity

Haleden Chiririwa; John R. Moss; Denver Hendricks; Reinout Meijboom; Alfred Muller

doi:10.1007/s11243-012-9674-4

Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity

Haleden Chiririwa, John R. Moss, Denver Hendricks, Reinout Meijboom, Alfred Muller

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl₂(COD)] and [PdMeCl(COD)] in CH₂Cl₂ at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (¹H and ³¹P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC₅₀ range of 19.02-45.27 μM, and IC₅₀ range of 10.03-68.54 μM for the KYSE450 cell lines.

Original language	English
Pages (from-to)	165-172
Number of pages	8
Journal	Transition Metal Chemistry
Volume	38
Issue number	2
DOIs	https://doi.org/10.1007/s11243-012-9674-4
Publication status	Published - Mar 2013

ASJC Scopus subject areas

Inorganic Chemistry
Metals and Alloys
Materials Chemistry

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title = "Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity",

abstract = "Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines.",

author = "Haleden Chiririwa and Moss, \{John R.\} and Denver Hendricks and Reinout Meijboom and Alfred Muller",

year = "2013",

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doi = "10.1007/s11243-012-9674-4",

language = "English",

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pages = "165--172",

journal = "Transition Metal Chemistry",

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TY - JOUR

T1 - Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity

AU - Chiririwa, Haleden

AU - Moss, John R.

AU - Hendricks, Denver

AU - Meijboom, Reinout

AU - Muller, Alfred

PY - 2013/3

Y1 - 2013/3

N2 - Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines.

AB - Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines.

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U2 - 10.1007/s11243-012-9674-4

DO - 10.1007/s11243-012-9674-4

M3 - Article

AN - SCOPUS:84876485335

SN - 0340-4285

VL - 38

SP - 165

EP - 172

JO - Transition Metal Chemistry

JF - Transition Metal Chemistry

IS - 2

ER -

Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity

Abstract

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