Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity

Haleden Chiririwa, John R. Moss, Denver Hendricks, Reinout Meijboom, Alfred Muller

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalTransition Metal Chemistry
Volume38
Issue number2
DOIs
Publication statusPublished - Mar 2013

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Metals and Alloys
  • Materials Chemistry

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