TY - JOUR
T1 - Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity
AU - Chiririwa, Haleden
AU - Moss, John R.
AU - Hendricks, Denver
AU - Meijboom, Reinout
AU - Muller, Alfred
PY - 2013/3
Y1 - 2013/3
N2 - Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines.
AB - Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines.
UR - http://www.scopus.com/inward/record.url?scp=84876485335&partnerID=8YFLogxK
U2 - 10.1007/s11243-012-9674-4
DO - 10.1007/s11243-012-9674-4
M3 - Article
AN - SCOPUS:84876485335
SN - 0340-4285
VL - 38
SP - 165
EP - 172
JO - Transition Metal Chemistry
JF - Transition Metal Chemistry
IS - 2
ER -