Synthesis, characterisation and DFT studies of [3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl](phenyl)methanone derivatives

Louis Charl C. Coetzee, Alfred J. Muller, Adedapo S. Adeyinka, Molahlehi S. Sonopo, D. Bradley G. Williams

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Three 1,2,4-triazole derivatives have been synthesised from hydrazides and 2-(2-hydroxyphenyl)-4H-1,3-benzoaxin-4-one. With the aid of Conceptual Density Functional Theory (CDFT), Molecular Electrostatic Potential (MEP) and Quantum Theory of Atoms in Molecules (QTAIM) analysis, the effect of incorporating para-substituted moieties on the hydrazides were investigated for both successful and unsuccessful reactions, as well as reactivities for the former. 1H- and 13C NMR, FT-IR and HRMS were used to characterize these compounds.

Original languageEnglish
Article number100165
JournalResults in Chemistry
Publication statusPublished - Jan 2021


  • 1,2,4-triazoles
  • Electronic effects
  • Hyperconjugation
  • Inductive effects

ASJC Scopus subject areas

  • General Chemistry


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