Synthesis, characterisation and biological activities of Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine

M. O. Agwara; M. D. Yufanyi; J. N. Foba-Tendo; M. A. Atamba; Derek Tantoh Ndinteh

Synthesis, characterisation and biological activities of Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine

M. O. Agwara
, M. D. Yufanyi
, J. N. Foba-Tendo
, M. A. Atamba
, Derek Tantoh Ndinteh

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine (HMTA) have been synthesized in water and ethanol. All the complexes are hydrogen-bonded, except the cobalt complex [Co(HMTA) ₂(NO ₃) ₂(H ₂O) ₂] which is polymeric. These complexes have been characterized by elemental analyses, infrared and visible spectroscopy as well as conductivity. The results suggest octahedral coordination in which the central metal ion is bonded to aqua ligands and the HMTA is bonded to the aqua ligands through hydrogen-bonding. Antibacterial activities of the ligand and its complexes show that the ligand is active against 1 out of 10 tested bacteria species; the cobalt complexes [Co(H ₂O) ₆](HMTA) ₂(NO ₃) ₂. 4H ₂O, and [Co(HMTA) ₂(NO ₃) ₂(H ₂O) ₂] are the most active, showing activity against all the microorganisms. These cobalt complexes also show greater activity than the reference antibiotic gentamycin against Klebsiella pneumonia.

Original language	English
Pages (from-to)	196-204
Number of pages	9
Journal	Journal of Chemical and Pharmaceutical Research
Volume	3
Issue number	3
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimicrobial
Co(II)
Hexamethylenetetamine
Mn(II)
Ni(II)

ASJC Scopus subject areas

Pharmaceutical Science

Cite this

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title = "Synthesis, characterisation and biological activities of Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine",

abstract = "Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine (HMTA) have been synthesized in water and ethanol. All the complexes are hydrogen-bonded, except the cobalt complex [Co(HMTA) 2(NO 3) 2(H 2O) 2] which is polymeric. These complexes have been characterized by elemental analyses, infrared and visible spectroscopy as well as conductivity. The results suggest octahedral coordination in which the central metal ion is bonded to aqua ligands and the HMTA is bonded to the aqua ligands through hydrogen-bonding. Antibacterial activities of the ligand and its complexes show that the ligand is active against 1 out of 10 tested bacteria species; the cobalt complexes [Co(H 2O) 6](HMTA) 2(NO 3) 2. 4H 2O, and [Co(HMTA) 2(NO 3) 2(H 2O) 2] are the most active, showing activity against all the microorganisms. These cobalt complexes also show greater activity than the reference antibiotic gentamycin against Klebsiella pneumonia.",

keywords = "Antimicrobial, Co(II), Hexamethylenetetamine, Mn(II), Ni(II)",

author = "Agwara, \{M. O.\} and Yufanyi, \{M. D.\} and Foba-Tendo, \{J. N.\} and Atamba, \{M. A.\} and Ndinteh, \{Derek Tantoh\}",

year = "2011",

language = "English",

volume = "3",

pages = "196--204",

journal = "Journal of Chemical and Pharmaceutical Research",

issn = "0975-7384",

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TY - JOUR

T1 - Synthesis, characterisation and biological activities of Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine

AU - Agwara, M. O.

AU - Yufanyi, M. D.

AU - Foba-Tendo, J. N.

AU - Atamba, M. A.

AU - Ndinteh, Derek Tantoh

PY - 2011

Y1 - 2011

N2 - Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine (HMTA) have been synthesized in water and ethanol. All the complexes are hydrogen-bonded, except the cobalt complex [Co(HMTA) 2(NO 3) 2(H 2O) 2] which is polymeric. These complexes have been characterized by elemental analyses, infrared and visible spectroscopy as well as conductivity. The results suggest octahedral coordination in which the central metal ion is bonded to aqua ligands and the HMTA is bonded to the aqua ligands through hydrogen-bonding. Antibacterial activities of the ligand and its complexes show that the ligand is active against 1 out of 10 tested bacteria species; the cobalt complexes [Co(H 2O) 6](HMTA) 2(NO 3) 2. 4H 2O, and [Co(HMTA) 2(NO 3) 2(H 2O) 2] are the most active, showing activity against all the microorganisms. These cobalt complexes also show greater activity than the reference antibiotic gentamycin against Klebsiella pneumonia.

AB - Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine (HMTA) have been synthesized in water and ethanol. All the complexes are hydrogen-bonded, except the cobalt complex [Co(HMTA) 2(NO 3) 2(H 2O) 2] which is polymeric. These complexes have been characterized by elemental analyses, infrared and visible spectroscopy as well as conductivity. The results suggest octahedral coordination in which the central metal ion is bonded to aqua ligands and the HMTA is bonded to the aqua ligands through hydrogen-bonding. Antibacterial activities of the ligand and its complexes show that the ligand is active against 1 out of 10 tested bacteria species; the cobalt complexes [Co(H 2O) 6](HMTA) 2(NO 3) 2. 4H 2O, and [Co(HMTA) 2(NO 3) 2(H 2O) 2] are the most active, showing activity against all the microorganisms. These cobalt complexes also show greater activity than the reference antibiotic gentamycin against Klebsiella pneumonia.

KW - Antimicrobial

KW - Co(II)

KW - Hexamethylenetetamine

KW - Mn(II)

KW - Ni(II)

UR - https://www.scopus.com/pages/publications/79957890594

M3 - Article

AN - SCOPUS:79957890594

SN - 0975-7384

VL - 3

SP - 196

EP - 204

JO - Journal of Chemical and Pharmaceutical Research

JF - Journal of Chemical and Pharmaceutical Research

IS - 3

ER -

Synthesis, characterisation and biological activities of Mn(II), Co(II) and Ni(II) complexes of hexamethylenetetramine

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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