Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives

Yonas Belay; Alfred Muller; Derek T. Ndinteh; Oyebamiji A. Kolawole; Adedapo S. Adeyinka; Thierry Y. Fonkui

doi:10.1016/j.molstruc.2022.134623

Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives

Yonas Belay, Alfred Muller, Derek T. Ndinteh, Oyebamiji A. Kolawole, Adedapo S. Adeyinka, Thierry Y. Fonkui

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A series of Schiff bases (1–15) were synthesized by reacting salicylaldehyde with series of primary amines. Their chemical structures were characterized using ¹H NMR, ¹³C{H} NMR, FTIR and CHN-elemental analyses. Antibacterial activities against eleven strains of bacteria showed that all the compounds exhibited good antibacterial activities at different concentration levels. From the minimum inhibitory concentration and cytotoxicity studies, compounds 4, 12 and 15 were selected as the most potent potential drug candidates against Bacillus subtilis (BS), Enterococcus faecalis (EF), Staphylococcus aureus (SA) and Proteus mirabilis (PM). The presence of pyridine and morpholine subunits in compounds 4 and 12 as well as 15, was found to be responsible for the greater degree of potency recorded for these compounds as also confirmed using computational and molecular docking studies.

Original language	English
Article number	134623
Journal	Journal of Molecular Structure
Volume	1275
DOIs	https://doi.org/10.1016/j.molstruc.2022.134623
Publication status	Published - 5 Mar 2023

Keywords

Cytotoxicity
Drug resistance
Minimum inhibitory concentration (MIC)
Molecular docking
Salicylaldehyde
Schiff bases

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy
Organic Chemistry
Inorganic Chemistry

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10.1016/j.molstruc.2022.134623

Cite this

@article{19aa2f60db404310a1c04c6dbb05c8e3,

title = "Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives",

abstract = "A series of Schiff bases (1–15) were synthesized by reacting salicylaldehyde with series of primary amines. Their chemical structures were characterized using 1H NMR, 13C{H} NMR, FTIR and CHN-elemental analyses. Antibacterial activities against eleven strains of bacteria showed that all the compounds exhibited good antibacterial activities at different concentration levels. From the minimum inhibitory concentration and cytotoxicity studies, compounds 4, 12 and 15 were selected as the most potent potential drug candidates against Bacillus subtilis (BS), Enterococcus faecalis (EF), Staphylococcus aureus (SA) and Proteus mirabilis (PM). The presence of pyridine and morpholine subunits in compounds 4 and 12 as well as 15, was found to be responsible for the greater degree of potency recorded for these compounds as also confirmed using computational and molecular docking studies.",

keywords = "Cytotoxicity, Drug resistance, Minimum inhibitory concentration (MIC), Molecular docking, Salicylaldehyde, Schiff bases",

author = "Yonas Belay and Alfred Muller and Ndinteh, {Derek T.} and Kolawole, {Oyebamiji A.} and Adeyinka, {Adedapo S.} and Fonkui, {Thierry Y.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

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day = "5",

doi = "10.1016/j.molstruc.2022.134623",

language = "English",

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journal = "Journal of Molecular Structure",

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T1 - Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives

AU - Belay, Yonas

AU - Muller, Alfred

AU - Ndinteh, Derek T.

AU - Kolawole, Oyebamiji A.

AU - Adeyinka, Adedapo S.

AU - Fonkui, Thierry Y.

PY - 2023/3/5

Y1 - 2023/3/5

N2 - A series of Schiff bases (1–15) were synthesized by reacting salicylaldehyde with series of primary amines. Their chemical structures were characterized using 1H NMR, 13C{H} NMR, FTIR and CHN-elemental analyses. Antibacterial activities against eleven strains of bacteria showed that all the compounds exhibited good antibacterial activities at different concentration levels. From the minimum inhibitory concentration and cytotoxicity studies, compounds 4, 12 and 15 were selected as the most potent potential drug candidates against Bacillus subtilis (BS), Enterococcus faecalis (EF), Staphylococcus aureus (SA) and Proteus mirabilis (PM). The presence of pyridine and morpholine subunits in compounds 4 and 12 as well as 15, was found to be responsible for the greater degree of potency recorded for these compounds as also confirmed using computational and molecular docking studies.

AB - A series of Schiff bases (1–15) were synthesized by reacting salicylaldehyde with series of primary amines. Their chemical structures were characterized using 1H NMR, 13C{H} NMR, FTIR and CHN-elemental analyses. Antibacterial activities against eleven strains of bacteria showed that all the compounds exhibited good antibacterial activities at different concentration levels. From the minimum inhibitory concentration and cytotoxicity studies, compounds 4, 12 and 15 were selected as the most potent potential drug candidates against Bacillus subtilis (BS), Enterococcus faecalis (EF), Staphylococcus aureus (SA) and Proteus mirabilis (PM). The presence of pyridine and morpholine subunits in compounds 4 and 12 as well as 15, was found to be responsible for the greater degree of potency recorded for these compounds as also confirmed using computational and molecular docking studies.

KW - Cytotoxicity

KW - Drug resistance

KW - Minimum inhibitory concentration (MIC)

KW - Molecular docking

KW - Salicylaldehyde

KW - Schiff bases

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U2 - 10.1016/j.molstruc.2022.134623

DO - 10.1016/j.molstruc.2022.134623

M3 - Article

AN - SCOPUS:85142884862

SN - 0022-2860

VL - 1275

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 134623

ER -

Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives

Abstract

Keywords

ASJC Scopus subject areas

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New Antibiotics Study Results Reported from University of Johannesburg (Synthesis, Antibacterial Activities, Cytotoxicity, and Molecular Docking Studies of Salicyledene Derivatives)

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Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

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New Antibiotics Study Results Reported from University of Johannesburg (Synthesis, Antibacterial Activities, Cytotoxicity, and Molecular Docking Studies of Salicyledene Derivatives)

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