Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

Nikiwe Mhlanga; Suprakas Sinha Ray

doi:10.1063/1.4918443

Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

Nikiwe Mhlanga, Suprakas Sinha Ray

Chemical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

Original language	English
Title of host publication	Proceedings of PPS-30
Subtitle of host publication	The 30th International Conference of the Polymer Processing Society - Conference Papers
Editors	Sadhan C. Jana
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735413092
DOIs	https://doi.org/10.1063/1.4918443
Publication status	Published - 22 May 2015
Event	30th International Conference of the Polymer Processing Society, PPS 2014 - Cleveland, United States Duration: 6 Jun 2014 → 12 Jun 2014

Publication series

Name	AIP Conference Proceedings
Volume	1664
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	30th International Conference of the Polymer Processing Society, PPS 2014
Country/Territory	United States
City	Cleveland
Period	6/06/14 → 12/06/14

Keywords

Cancer
Drug delivery
Magnetic iron oxide
Polymer-based composites

ASJC Scopus subject areas

General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1063/1.4918443

Cite this

Mhlanga, N., & Ray, S. S. (2015). Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery. In S. C. Jana (Ed.), Proceedings of PPS-30: The 30th International Conference of the Polymer Processing Society - Conference Papers Article 700081 (AIP Conference Proceedings; Vol. 1664). American Institute of Physics Inc.. https://doi.org/10.1063/1.4918443

@inproceedings{69d972531abe46f8966f192176b3edda,

title = "Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery",

abstract = "Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.",

keywords = "Cancer, Drug delivery, Magnetic iron oxide, Polymer-based composites",

author = "Nikiwe Mhlanga and Ray, {Suprakas Sinha}",

note = "Publisher Copyright: {\textcopyright} 2015 AIP Publishing LLC.; 30th International Conference of the Polymer Processing Society, PPS 2014 ; Conference date: 06-06-2014 Through 12-06-2014",

year = "2015",

month = may,

day = "22",

doi = "10.1063/1.4918443",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Jana, {Sadhan C.}",

booktitle = "Proceedings of PPS-30",

}

Mhlanga, N & Ray, SS 2015, Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery. in SC Jana (ed.), Proceedings of PPS-30: The 30th International Conference of the Polymer Processing Society - Conference Papers., 700081, AIP Conference Proceedings, vol. 1664, American Institute of Physics Inc., 30th International Conference of the Polymer Processing Society, PPS 2014, Cleveland, United States, 6/06/14. https://doi.org/10.1063/1.4918443

Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery. / Mhlanga, Nikiwe; Ray, Suprakas Sinha.
Proceedings of PPS-30: The 30th International Conference of the Polymer Processing Society - Conference Papers. ed. / Sadhan C. Jana. American Institute of Physics Inc., 2015. 700081 (AIP Conference Proceedings; Vol. 1664).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

AU - Mhlanga, Nikiwe

AU - Ray, Suprakas Sinha

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

AB - Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

KW - Cancer

KW - Drug delivery

KW - Magnetic iron oxide

KW - Polymer-based composites

UR - http://www.scopus.com/inward/record.url?scp=84984562977&partnerID=8YFLogxK

U2 - 10.1063/1.4918443

DO - 10.1063/1.4918443

M3 - Conference contribution

AN - SCOPUS:84984562977

T3 - AIP Conference Proceedings

BT - Proceedings of PPS-30

A2 - Jana, Sadhan C.

PB - American Institute of Physics Inc.

T2 - 30th International Conference of the Polymer Processing Society, PPS 2014

Y2 - 6 June 2014 through 12 June 2014

ER -

Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this