Synthesis and characterization of polyamidoamine conjugates of neridronic acid

B. A. Aderibigbe; E. R. Sadiku; S. Sinha Ray; X. Y. Mbianda; M. C. Fotsing; S. C. Agwuncha; S. J. Owonubi

doi:10.1007/s00289-014-1286-z

Synthesis and characterization of polyamidoamine conjugates of neridronic acid

B. A. Aderibigbe, E. R. Sadiku, S. Sinha Ray, X. Y. Mbianda, M. C. Fotsing, S. C. Agwuncha, S. J. Owonubi

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Polyamidoamine conjugates of neridronic acid were synthesized by a one-pot aqueous phase Michael addition reaction of N, N′-methylenebisacrylamide with selected primary and secondary amines and neridronic acid. This reaction involved the use of water and it was performed at room temperature thereby making the reaction environmentally friendly and economically viable. These conjugates are potential prodrugs and they were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and energy-dispersive X-ray analysis (EDX). NMR, TGA, XRD and FTIR confirmed the successful incorporation of the bisphosphonate on to the carriers. The mass percentage incorporation of neridronic acid was found to be between 0.9 and 3.74 percent. ³¹P NMR exhibited the signal peak for the bisphosphonate at 19.0 ppm.

Original language	English
Pages (from-to)	417-439
Number of pages	23
Journal	Polymer Bulletin
Volume	72
Issue number	3
DOIs	https://doi.org/10.1007/s00289-014-1286-z
Publication status	Published - Mar 2015

Keywords

Anticancer
Michael addition
Neridronic acid
Polyamidoamines
Polymeric conjugates

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Polymers and Plastics
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00289-014-1286-z

Cite this

@article{8a69ba5c09b9475c9f9400362ecc6bbf,

title = "Synthesis and characterization of polyamidoamine conjugates of neridronic acid",

abstract = "Polyamidoamine conjugates of neridronic acid were synthesized by a one-pot aqueous phase Michael addition reaction of N, N′-methylenebisacrylamide with selected primary and secondary amines and neridronic acid. This reaction involved the use of water and it was performed at room temperature thereby making the reaction environmentally friendly and economically viable. These conjugates are potential prodrugs and they were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and energy-dispersive X-ray analysis (EDX). NMR, TGA, XRD and FTIR confirmed the successful incorporation of the bisphosphonate on to the carriers. The mass percentage incorporation of neridronic acid was found to be between 0.9 and 3.74 percent. 31P NMR exhibited the signal peak for the bisphosphonate at 19.0 ppm.",

keywords = "Anticancer, Michael addition, Neridronic acid, Polyamidoamines, Polymeric conjugates",

author = "Aderibigbe, {B. A.} and Sadiku, {E. R.} and {Sinha Ray}, S. and Mbianda, {X. Y.} and Fotsing, {M. C.} and Agwuncha, {S. C.} and Owonubi, {S. J.}",

note = "Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",

year = "2015",

month = mar,

doi = "10.1007/s00289-014-1286-z",

language = "English",

volume = "72",

pages = "417--439",

journal = "Polymer Bulletin",

issn = "0170-0839",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - Synthesis and characterization of polyamidoamine conjugates of neridronic acid

AU - Aderibigbe, B. A.

AU - Sadiku, E. R.

AU - Sinha Ray, S.

AU - Mbianda, X. Y.

AU - Fotsing, M. C.

AU - Agwuncha, S. C.

AU - Owonubi, S. J.

PY - 2015/3

Y1 - 2015/3

N2 - Polyamidoamine conjugates of neridronic acid were synthesized by a one-pot aqueous phase Michael addition reaction of N, N′-methylenebisacrylamide with selected primary and secondary amines and neridronic acid. This reaction involved the use of water and it was performed at room temperature thereby making the reaction environmentally friendly and economically viable. These conjugates are potential prodrugs and they were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and energy-dispersive X-ray analysis (EDX). NMR, TGA, XRD and FTIR confirmed the successful incorporation of the bisphosphonate on to the carriers. The mass percentage incorporation of neridronic acid was found to be between 0.9 and 3.74 percent. 31P NMR exhibited the signal peak for the bisphosphonate at 19.0 ppm.

AB - Polyamidoamine conjugates of neridronic acid were synthesized by a one-pot aqueous phase Michael addition reaction of N, N′-methylenebisacrylamide with selected primary and secondary amines and neridronic acid. This reaction involved the use of water and it was performed at room temperature thereby making the reaction environmentally friendly and economically viable. These conjugates are potential prodrugs and they were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and energy-dispersive X-ray analysis (EDX). NMR, TGA, XRD and FTIR confirmed the successful incorporation of the bisphosphonate on to the carriers. The mass percentage incorporation of neridronic acid was found to be between 0.9 and 3.74 percent. 31P NMR exhibited the signal peak for the bisphosphonate at 19.0 ppm.

KW - Anticancer

KW - Michael addition

KW - Neridronic acid

KW - Polyamidoamines

KW - Polymeric conjugates

UR - http://www.scopus.com/inward/record.url?scp=84925499957&partnerID=8YFLogxK

U2 - 10.1007/s00289-014-1286-z

DO - 10.1007/s00289-014-1286-z

M3 - Article

AN - SCOPUS:84925499957

SN - 0170-0839

VL - 72

SP - 417

EP - 439

JO - Polymer Bulletin

JF - Polymer Bulletin

IS - 3

ER -

Synthesis and characterization of polyamidoamine conjugates of neridronic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this