Abstract
Novel poly (Vinyl acetate-co-Methacrylic acid) poly (VAc-co-MAA) copolymeric microspheres have been prepared by free radical emulsion polymerization using varying amounts of methacrylic acid, vinyl acetate (VAc) and N, N'-methylene bis acrylamide (NNMBA). These microspheres are crosslinked with N, N'-methylenebisacrylamide. Acebutolol hydrochloride an antihypertensive drug was loaded into these microspheres during in situ polymerization. The microspheres have been characterized by differential scanning calorimetry (DSC) and x-ray diffractometry (X-RD) to understand about the drug dispersion in microspheres and noticed that the drug dispersed in molecular level in microspheres. Scanning electron microscopy (SEM) was used to assess the surface morphology of particles prepared. In vitro release of Acebutolol hydrochloride has been studied in terms of copolymer composition, amount of cross-linking agent and amount of Acebutolol hydrochloride in the microspheres. Microspheres with different copolymer compositions have been prepared with yield up to ranging 80-85%. In vitro dissolution experiments performed in phosphate buffer pH 7.4 medium indicated the controlled release of Acebutolol hydrochloride from the microspheres up to 14 h.
Original language | English |
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Title of host publication | Micro- and Nanostructured Polymer Systems |
Subtitle of host publication | From Synthesis to Applications |
Publisher | CRC Press |
Pages | 101-118 |
Number of pages | 18 |
ISBN (Electronic) | 9781498721592 |
ISBN (Print) | 9781771881005 |
Publication status | Published - 5 Jan 2016 |
Keywords
- Copolymer
- Drug delivery
- Microspheres
- pH Sensitive
ASJC Scopus subject areas
- General Engineering
- General Materials Science