Synthesis and characterization of pH sensitive poly(Vinyl Acetate-co-Methacrylic acid) microspheres for control release of Acebutolol hydrochloride

V. Rajinee Kant, S. Ravindra, K. Chowdojirao, S. G. Adoor, F. Antoine Mulaba-Bafubiandi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Novel poly (Vinyl acetate-co-Methacrylic acid) poly (VAc-co-MAA) copolymeric microspheres have been prepared by free radical emulsion polymerization using varying amounts of methacrylic acid, vinyl acetate (VAc) and N, N'-methylene bis acrylamide (NNMBA). These microspheres are crosslinked with N, N'-methylenebisacrylamide. Acebutolol hydrochloride an antihypertensive drug was loaded into these microspheres during in situ polymerization. The microspheres have been characterized by differential scanning calorimetry (DSC) and x-ray diffractometry (X-RD) to understand about the drug dispersion in microspheres and noticed that the drug dispersed in molecular level in microspheres. Scanning electron microscopy (SEM) was used to assess the surface morphology of particles prepared. In vitro release of Acebutolol hydrochloride has been studied in terms of copolymer composition, amount of cross-linking agent and amount of Acebutolol hydrochloride in the microspheres. Microspheres with different copolymer compositions have been prepared with yield up to ranging 80-85%. In vitro dissolution experiments performed in phosphate buffer pH 7.4 medium indicated the controlled release of Acebutolol hydrochloride from the microspheres up to 14 h.

Original languageEnglish
Title of host publicationMicro- and Nanostructured Polymer Systems
Subtitle of host publicationFrom Synthesis to Applications
PublisherCRC Press
Pages101-118
Number of pages18
ISBN (Electronic)9781498721592
ISBN (Print)9781771881005
Publication statusPublished - 5 Jan 2016

Keywords

  • Copolymer
  • Drug delivery
  • Microspheres
  • pH Sensitive

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science

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